Review
doi: 10.1016/j.mce.2009.08.009.
Epub 2009 Aug 19.
Interactions of sex hormone-binding globulin with target cells
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- PMID: 19698759
- DOI: 10.1016/j.mce.2009.08.009
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Review
Interactions of sex hormone-binding globulin with target cells
Mol Cell Endocrinol.
.
Abstract
Sex hormone-binding globulin (SHBG) was initially described as a plasma protein synthesized in, and secreted by, the liver. It was discovered by its ability to bind certain androgens and estrogens and, for many years, was believed to serve as a transporter/reservoir for the steroids which it bound. Subsequently, it became clear that the cell membranes of selected tissues contained a receptor for SHBG (R(SHBG)). This review deals with what is known of that receptor - its anatomy, physiology and biochemistry.
2009 Elsevier Ireland Ltd. All rights reserved.
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