Abstract

We recently dissected how senescent tumors can trigger complementing signaling pathways that mobilize natural killer cells to eliminate malignant cells. In addition to cell-intrinsic effects on proliferation, senescence induces the production of chemokine ligand 2, which recruits NK cells to mediate direct tumoricidal effects. Hence, senescence activates a cancer cell-extrinsic oncosuppression program. © 2014 Landes Bioscience.