Entry - *621105 - ETS VARIANT TRANSCRIPTION FACTOR 3-LIKE; ETV3L - OMIM - (OMIM.ORG)

 
 
* 621105

ETS VARIANT TRANSCRIPTION FACTOR 3-LIKE; ETV3L


Alternative titles; symbols

ETV3-LIKE


HGNC Approved Gene Symbol: ETV3L

Cytogenetic location: 1q23.1   Genomic coordinates (GRCh38) : 1:157,092,043-157,099,808 (from NCBI)


TEXT

▼ Description

ETV3L is a transcription factor that appears to function as a retinoic acid (RA)-inducible repressor (Janesick et al., 2013).


► Gene Function

Using in situ hybridization, Janesick et al. (2013) showed that RA receptor (RAR; see 180240) signaling induced neuronal differentiation and inhibited proproliferative neural markers in Xenopus embryos. Further analysis identified Erf (611888), Etv3 (164873), and Etv3l as RAR-responsive repressors expressed in neuroectoderm. Erf or Etv3/Etv3l knockdown inhibited the neural differentiation pathway and expanded expression of neural progenitor markers in Xenopus embryos. Moreover, knockdown of Erf or Etv3l promoted proliferation in the neural plate in Xenopus embryos, whereas Erf overexpression led to an increase of neurons.

Cao et al. (2018) characterized of the promoter region of LAIR1 (602992) and identified several ETS family members, including ETV3L, as enhancers of LAIR1 basic promoter activity. Ectopic expression in HO8910 ovarian cancer cells confirmed that ETV3L enhanced LAIR1 protein expression.


► Mapping

Gross (2025) mapped the ETV3L gene to chromosome 1q23.1 based on an alignment of the ETV3L sequence (GenBank NM_001004341) with the genomic sequence (GRCh38).

► REFERENCES

  1. Cao, Q., Yang, S., Lv, Q., Liu, Y., Li, L., Wu, X., Qu, G., He, X., Zhang, X., Sun, S., Li, B., An, J., Hu, T., Xue, J. Five ETS family members, ELF-1, ETV-4, ETV-3L, ETS-1, and ETS-2 upregulate human leukocyte-associated immunoglobulin-like receptor-1 gene basic promoter activity. Aging 10: 1390-1401, 2018. [PubMed: 29915163, images, related citations] [Full Text]

  2. Gross, M. B. Personal Communication. Baltimore, Md. 2/21/2025.

  3. Janesick, A., Abbey, R., Chung, C., Liu, S., Taketani, M., Blumberg, B. ERF and ETV3L are retinoic acid-inducible repressors required for primary neurogenesis. Development 140: 3095-3106, 2013. [PubMed: 23824578, related citations] [Full Text]


Contributors:
Matthew B. Gross - updated : 02/21/2025
Creation Date:
Bao Lige : 02/21/2025
Edit History:
mgross : 02/21/2025

* 621105

ETS VARIANT TRANSCRIPTION FACTOR 3-LIKE; ETV3L


Alternative titles; symbols

ETV3-LIKE


HGNC Approved Gene Symbol: ETV3L

Cytogenetic location: 1q23.1   Genomic coordinates (GRCh38) : 1:157,092,043-157,099,808 (from NCBI)


TEXT

Description

ETV3L is a transcription factor that appears to function as a retinoic acid (RA)-inducible repressor (Janesick et al., 2013).


Gene Function

Using in situ hybridization, Janesick et al. (2013) showed that RA receptor (RAR; see 180240) signaling induced neuronal differentiation and inhibited proproliferative neural markers in Xenopus embryos. Further analysis identified Erf (611888), Etv3 (164873), and Etv3l as RAR-responsive repressors expressed in neuroectoderm. Erf or Etv3/Etv3l knockdown inhibited the neural differentiation pathway and expanded expression of neural progenitor markers in Xenopus embryos. Moreover, knockdown of Erf or Etv3l promoted proliferation in the neural plate in Xenopus embryos, whereas Erf overexpression led to an increase of neurons.

Cao et al. (2018) characterized of the promoter region of LAIR1 (602992) and identified several ETS family members, including ETV3L, as enhancers of LAIR1 basic promoter activity. Ectopic expression in HO8910 ovarian cancer cells confirmed that ETV3L enhanced LAIR1 protein expression.


Mapping

Gross (2025) mapped the ETV3L gene to chromosome 1q23.1 based on an alignment of the ETV3L sequence (GenBank NM_001004341) with the genomic sequence (GRCh38).

REFERENCES

  1. Cao, Q., Yang, S., Lv, Q., Liu, Y., Li, L., Wu, X., Qu, G., He, X., Zhang, X., Sun, S., Li, B., An, J., Hu, T., Xue, J. Five ETS family members, ELF-1, ETV-4, ETV-3L, ETS-1, and ETS-2 upregulate human leukocyte-associated immunoglobulin-like receptor-1 gene basic promoter activity. Aging 10: 1390-1401, 2018. [PubMed: 29915163] [Full Text: https://doi.org/10.18632/aging.101475]

  2. Gross, M. B. Personal Communication. Baltimore, Md. 2/21/2025.

  3. Janesick, A., Abbey, R., Chung, C., Liu, S., Taketani, M., Blumberg, B. ERF and ETV3L are retinoic acid-inducible repressors required for primary neurogenesis. Development 140: 3095-3106, 2013. [PubMed: 23824578] [Full Text: https://doi.org/10.1242/dev.093716]


Contributors:
Matthew B. Gross - updated : 02/21/2025

Creation Date:
Bao Lige : 02/21/2025

Edit History:
mgross : 02/21/2025



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OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2026 Johns Hopkins University.

NOTE: OMIM is intended for use primarily by physicians and other professionals concerned with genetic disorders, by genetics researchers, and by advanced students in science and medicine. While the OMIM database is open to the public, users seeking information about a personal medical or genetic condition are urged to consult with a qualified physician for diagnosis and for answers to personal questions.
OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2026 Johns Hopkins University.
Printed: May 26, 2026