Alternative titles; symbols
HGNC Approved Gene Symbol: MRGPRF
Cytogenetic location: 11q13.3 Genomic coordinates (GRCh38) : 11:69,004,398-69,013,633 (from NCBI)
Ross et al. (1990) cloned rat Mrgprf, which they called Rta. The deduced 343-amino acid protein has 7 transmembrane domains and is most closely related to the human MAS1 oncogene (165180), with which it shares 34% amino acid identity.
Dong et al. (2001) identified, in the mouse and human genomes, a family of G protein-coupled receptors (GPCRs) related to the MAS1 oncogene, including MRGPRF, which they called MRGF. Several pseudogenes were also identified. The predicted MRG proteins contain transmembrane, extracellular, and cytoplasmic domains. A subset of MRGs was expressed in specific subpopulations of sensory neurons that detect painful stimuli. The expression patterns of these genes thus revealed an unexpected degree of molecular diversity among nociceptive neurons. Some MRGs could be specifically activated in heterologous cells by RFamide neuropeptides, such as NPFF and NPAF (see 604643), which are analgesic in vivo. The authors concluded that MRGs may regulate nociceptor function and/or development, including the sensation or modulation of pain.
By genomic sequence analysis, Dong et al. (2001) mapped the MRGF gene to chromosome 11.
Dong, X., Han, S., Zylka, M. J., Simon, M. I., Anderson, D. J. A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons. Cell 106: 619-632, 2001. [PubMed: 11551509] [Full Text: https://doi.org/10.1016/s0092-8674(01)00483-4]
Ross, P. C., Figler, R. A., Corjay, M. H., Barber, C. M., Adam, N., Harcus, D. R., Lynch, K. R. RTA, a candidate G protein-coupled receptor: cloning, sequencing, and tissue distribution. Proc. Nat. Acad. Sci. 87: 3052-3056, 1990. [PubMed: 2109324] [Full Text: https://doi.org/10.1073/pnas.87.8.3052]