Alternative titles; symbols
HGNC Approved Gene Symbol: PKMYT1
Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38) : 16:2,972,808-2,980,446 (from NCBI)
Entry into mitosis requires the activity of CDC2 kinase (116940) coupled with cyclin B. Phosphorylation of the CDC2 protein on residues threonine 14 and tyrosine 15 is inhibitory to CDC2 activity. Using a PCR-based approach, Liu et al. (1997) cloned a novel kinase, which they termed MYT1 for 'membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase', that phosphorylates CDC2 on both threonine 14 and tyrosine 15. Preferentially, MYT1 phosphorylates CDC2 on threonine 14 in a cyclin-dependent manner. The MYT1 cDNA encodes a predicted 499-amino acid polypeptide with a molecular mass of 55 kD. Liu et al. (1997) found that the protein localizes to the endoplasmic reticulum and Golgi complex in HeLa cells.
Although Liu et al. (1997) designated this gene MYT1, this symbol had already been assigned to the myelin transcription factor-1 gene (600379).
Liu, F., Stanton, J. J., Wu, Z., Piwnica-Worms, H. The human myt1 kinase preferentially phosphorylates cdc2 on threonine 14 and localizes to the endoplasmic reticulum and Golgi complex. Molec. Cell. Biol. 17: 571-583, 1997. [PubMed: 9001210] [Full Text: https://doi.org/10.1128/MCB.17.2.571]