Alternative titles; symbols
HGNC Approved Gene Symbol: HSPA6
Cytogenetic location: 1q23.3 Genomic coordinates (GRCh38) : 1:161,524,540-161,526,894 (from NCBI)
HSPA6 (HSP70B-prime) is a stress-induced heat-shock gene encoding a basic 70-kD protein. It is a close homolog of HSPA7 (140556), formerly designated HSP70B (Leung et al., 1990).
Leung et al. (1992) stated that both HSPA6 and HSPA7 represent functional genes, as determined by analyses of mRNA from heat-shocked human cells using sequence-specific oligonucleotides. After heat shock at 45 degrees C, HSPA6 mRNA was detected in fibroblast, HeLa, and Daudi cells, whereas HSPA7 mRNA was detected only in fibroblasts.
Parsian et al. (2000) found that HSPA6 and HSPA7 share 98% nucleotide identity through their putative coding regions. However, HSPA7 was predicted to lack protein-coding potential. Orthologs of HSPA6 and HSPA7 were not detected in mouse by Southern blot analysis.
Using RT-PCR, Parsian et al. (2000) detected the expression of HSPA6 and HSPA7 only after heat shock in human W138 and HeLa cells. HSPA6 was more strongly expressed following heat shock.
By hybridization analyses of a somatic cell hybrid DNA panel, Leung et al. (1992) found that HSPA6 and HSPA7 localize to 1q. A BamHI polymorphism in the HSPA7 gene was present in a predominantly Asian population.
Grosz et al. (1992) concluded that bovine HSP70-4 is homologous to HSPA6 or HSPA7 because it is syntenic with amylase-1 (104700) and PGM1 (171900), both of which are on human chromosome 1.
Using FISH, Parsian et al. (2000) mapped the HSPA6 and HSPA7 genes to within 5 to 10 Mb of each other on chromosome 1q23.1.
Brzustowicz et al. (2002) stated that the HSPA6 and HSPA7 genes are located on chromosome 1q22, according to sequence data provided by the Human Genome Project, and are in close proximity to a susceptibility locus for schizophrenia (604906).
Brzustowicz, L. M., Hayter, J. E., Hodgkinson, K. A., Chow, E. W. C., Bassett, A. S. Fine mapping of the schizophrenia susceptibility locus on chromosome 1q22. Hum. Hered. 54: 199-209, 2002. [PubMed: 12771552] [Full Text: https://doi.org/10.1159/000070665]
Grosz, M. D., Womack, J. E., Skow, L. C. Syntenic conservation of HSP70 genes in cattle and humans. Genomics 14: 863-868, 1992. [PubMed: 1478667] [Full Text: https://doi.org/10.1016/s0888-7543(05)80106-5]
Leung, T. K. C., Hall, C., Rajendran, M., Spurr, N. K., Lim, L. The human heat-shock genes HSPA6 and HSPA7 are both expressed and localize to chromosome 1. Genomics 12: 74-79, 1992. [PubMed: 1346391] [Full Text: https://doi.org/10.1016/0888-7543(92)90409-l]
Leung, T. K. C., Rajendran, M. Y., Monfries, C., Hall, C., Lim, L. The human heat-shock protein family: expression of a novel heat-inducible HSP70 (HSP70B-prime) and isolation of its cDNA and genomic DNA. Biochem. J. 267: 125-132, 1990. [PubMed: 2327978] [Full Text: https://doi.org/10.1042/bj2670125]
Parsian, A. J., Sheren, J. E., Tao, T. Y., Goswami, P. C., Malyapa, R., Van Rheeden, R., Watson, M. S., Hunt, C. R. The human Hsp70B gene at the HSPA7 locus of chromosome 1 is transcribed but non-functional. Biochim. Biophys. Acta 1494: 201-205, 2000. [PubMed: 11072087] [Full Text: https://doi.org/10.1016/s0167-4781(00)00203-7]