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Created by Stan Lee (b. 1922) and Jack Kirby (b. 1917).
First appearance in mainstream universe in Fantastic Four (Marvel, 1961 series) #1 (November 1961).
The Fantastic Four's past history is similar to that of the group on Earth-616, but there are some differences. Reed and Sue's son, Franklin is old enough to be a member of the team. Reed has turned Galactus into a star. Reed feels responsible for the release of the Terrigen Mists into the Earth's atmosphere, which is causing the mutation of all of the population, but this will later be revealed to have been caused by Black Bolt. Human Torch is killed in a battle by the Sub-Mariner. Sue and Dr. Doom are killed in a later fight while Doom is trying to kill Reed. Reed takes over Doom's position. Ben and Alicia get married and have two children: Buzz and Chuck, who have their father's mutation. Franklin becomes the new Galactus to restore the universe's balance. Mar-Vell helps resurrect Sue, and so the current line-up of the Fantastic Four/Grimm Family is: Mr. Fantastic [Reed Richards]; Invisible Woman [Susan Richards]; Thing [Ben Grimm]; Brothers Grimm [Buzz Grimm; Chuck Grimm].
First appearance in Earth-689 universe in The Avengers Annual (Marvel, 1967 series) #2 (September 1968).
First appearance in Earth-691 universe in Guardians of the Galaxy (Marvel, 1990 series) #24 [Direct] (May 1992).
First appearance in Earth-79715 universe in What If? (Marvel, 1977 series) #15 [Direct] (July 1979).