tuftsin


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tuftsin

 [tuft´sin]
a tetrapeptide cleaved from IgG that stimulates phagocytosis by neutrophils. It is produced primarily in the spleen; hereditary tuftsin deficiency and tuftsin deficiency following splenectomy result in increased susceptibility to certain infections.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

tuft·sin

(tŭf'sin),
A tetrapeptide derived from the Fc region of an immunoglobulin. Tuftsin enhances macrophage functions.
[Tufts University + -in]
Farlex Partner Medical Dictionary © Farlex 2012
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References in periodicals archive ?
Blednov et al., "The anxiolytic action of an analog of the endogenous peptide tuftsin on inbred mice with different phenotypes of the emotional stress reaction," Zhurnal Vysshei Nervnoi Deiatelnosti Imeni I P Pavlova, vol.
Peptide Selank Enhances the Effect of Diazepam in Reducing Anxiety in Unpredictable Chronic Mild Stress Conditions in Rats
Tsirka, "Modulation of microglial/macrophage activation by macrophage inhibitory factor (TKP) or tuftsin (TKPR) attenuates the disease course of experimental autoimmune encephalomyelitis," BMC Immunology, vol.
The contribution of immune and glial cell types in experimental autoimmune encephalomyelitis and multiple sclerosis
Tsirka, "Tuftsin promotes an anti-inflammatory switch and attenuates symptoms in experimental autoimmune encephalomyelitis," PLoS ONE, vol.
Microglia: an active player in the regulation of synaptic activity
Targeting of efavirenz loaded tuftsin conjugated poly(propyleneimine) dendrimers to HIV infected macrophages in vitro.
Ten thoughts on how HIV care may change in 10 years
Similar approaches were employed using tuftsin, a naturally occurring tetrapeptide known to induce phagocytosis, or ghrelin, which acts as an anti-inflammatory hormone [88, 89].
Role of Microglia in CNS autoimmunity
Cultures treated with tuftsin fragment1-3, a microglial/macrophage inhibitory factor (MIF), had less cytokine secretion.
Microglial responses after ischemic stroke and intracerebral hemorrhage
Tsirka, "Modulation of microglial/ macrophage activation by macrophage inhibitory factor (TKP) or tuftsin (TKPR) attenuates the disease course of experimental autoimmune encephalomyelitis," BMC Immunology, vol.
The benefits and detriments of macrophages/microglia in models of multiple sclerosis

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