ACE2

ACE2

(1) Angiotensin-Converting Enzyme 2. An angiotensin-converting enzyme (ACE-like exopeptidase of the dipeptidyl carboxydipeptidase family) which is expressed predominantly in vascular endothelial cells of the heart, kidney and testes.
Physiology ACE2 appears to be a critical regulator of heart function and may counteract ACE activity.
(2) A gene on Xp22 which encodes a variant of angiotensin converting enzyme of the dipeptidyl carboxydipeptidase family, which is expressed on the vascular endothelial cells of the heart, kidneys and testes.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

ACE2

Angiotensin-converting enzyme 2 Therapeutics An ACE-like enzyme expressed in vascular endothelial cells of the heart and kidney Physiology ACE2 appears to be a critical regulator of heart function and may counteract ACE activity. See ACE.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.
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References in periodicals archive ?
Oudit, "Role of angiotensin-converting enzyme 2 (ACE2) in diabetic cardiovascular complications," Clinical Science, vol.
Chronic treatment with Ang-(1-7) reverses abnormal reactivity in the corpus cavernosum and normalizes diabetes-induced changes in the protein levels of ACE, ACE2, ROCK1, ROCK2 and omega-hydroxylase in a rat model of type 1 diabetes
White AT cells, particularly white AT adipocytes, are capable of expressing all the RAAS components: angio-tensinogen, renin, angiotensin-converting enzyme (ACE), angiotensin II receptors (AT1 and AT2), as well as the components of the nonclassical pathway including ACE2 and MAS receptors for angiotensin (1-7).
New concepts in white adipose tissue physiology
Recently, a homologue of angiotensin converting enzyme (ACE), namely, ACE2 has been identified [6].
Ang (1-7) protects islet endothelial cells from palmitate-induced apoptosis by AkT, eNOS, p38 MAPK, and JNK Pathways
In high-dose STZ model, renal expression of RAS components was changed in a similar manner in STZ eNOS -/- and eNOS +/+ mice compared with nondiabetic counterparts as follows: (upregulated) angiotensinogen mRNA, ACE2, AT1 receptor, and MCR proteins, (downregulated) renin mRNA, and (unaltered) ACE protein.
Role of endothelial nitric oxide synthase in diabetic nephropathy: lessons from diabetic eNOS knockout mice
Ability to efficiently use the receptor molecules (ACE2 for human and civet) seems to be a major limiting factor for animal-to-human and human-to-human transmission (35).
Review of bats and SARS
The S1 subunit is responsible for virus binding to the receptor, angiotensin-converting enzyme 2 (ACE2) (15,16).
SARS vaccine development
To make the quail QT6/ACE2 cell line, the gene encoding the receptor for SARS-CoV, human angiotensin-converting enzyme 2 (ACE2) (35), was cloned from a human primary kidney cDNA library (Invitrogen, Paisley, Scotland, UK) using 21-mer primers designed to the start and stop of ACE2, and subcloned into pcdna3.1+.
Longitudinally profiling neutralizing antibody response to SARS coronavirus with pseudotypes

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