8-OHdG

8-hydroxy-2’-deoxyguanosine. A modified DNA nucleoside product generated by reactive oxygen species (ROS), which is elevated in colorectal carcinoma, but not in adenomas. 8-OHdG is also elevated in ulcerative colitis (UC) and increases with disease duration and dysplasia. MUTYH, the human mutY homologue, is responsible for excising misincorporated adenine and for suppressing mutations caused by ROS. Nuclear expression of MUTYH is attenuated in UC.

References in periodicals archive ?

Serum 8-hydroxy-2'-deoxyguanosine (8-OHdG), myoglobin, and cardiac troponin I (cTnI) levels were measured using kits based on the enzyme-linked immunosorbent assay (ELISA) principle.

Training Induced Oxidative Stress-Derived DNA and Muscle Damage in Triathletes

8-OhdG is an indicator of DNA oxidation (Piconi et al., 2003).

Efecto del Pasto de Trigo sobre el Dano del ADN, el Indice de Estres Oxidativo y los Hallazgos Histologicos en Ratas Diabeticas

Leukocyte counts, C-reactive protein (CRP)(high-sensitive CRP was employed from 2008 onwards), interleukin-6 (IL-6), and interferon gamma (IFN-[gamma]) were measured as representative inflammatory markers; sialylated carbohydrate antigen KL-6 (KL-6) and surfactant protein D (SP-D) were used as well-known markers of interstitial pneumonia; urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG) was used as a marker of oxidative stress; and immunoglobulin E (IgE) was measured as a marker of allergies.

THE RESPIRATORY EFFECTS OF TONER EXPOSURE ACCORDING TO LONG-TERM OCCUPATIONAL TONER HANDLING HISTORY: A LONGITUDINAL ANALYSIS, 2004-2013

8-Hydroxy-2'deoxyguanosine (8-OHdG) is believed to be one of the most abundant DNA lesions resulting from oxidative stress and is a biomarker of the oxidative DNA damage and repair.

Effect of Broussonetia papyrifera L. (paper mulberry) silage on dry matter intake, milk composition, antioxidant capacity and milk fatty acid profile in dairy cows

Piyodermali kopeklerde idrarda 8-hidroksi-2'-deoksiguanozin (8-OHdG) duzeyleri.

SOD, CAT, TBARS, and TNF-[alpha] Concentrations in Uterine Tissues of Bitches with Pyometra and at Dioestrus

We hypothesized that increase in 8-hydroxy-2'-deoxyguanosine (8-OHdG) level, DNA fragmentation in spermatozoa, changes in sperm mitochondrial membrane potential, and mitochondrial DNA damage should be preventable to some extent.

Moderate Dose of Trolox Preventing the Deleterious Effects of Wi-Fi Radiation on Spermatozoa In vitro through Reduction of Oxidative Stress Damage

"The osteoprotective effects of tocotrienol may be in part mediated through a reduction of oxidative stress, which was indicated by a 49% decrease in the oxidative stress marker 8-hydroxy-2'-deoxyguanosine (8-OHdG)."

What Women Want: Clean,Transparent & Personalized Products: Female consumers seek out nutritional products to curate personalized health regimens

[40] ocenili stezenie 8-hydroksy-2'deoksyguanozyny (8-OHdG) w moczu u 100 Wietnamczykow narazonych na podwyzszony poziom arsenu.

POLYMORPHISM OF GENES ENCODING PROTEINS OF DNA REPAIR VS. OCCUPATIONAL AND ENVIRONMENTAL EXPOSURE TO LEAD, ARSENIC AND PESTICIDES/ POLIMORFIZM GENOW KODUJACYCH BIALKA NAPRAWY DNA A ZAWODOWE I SRODOWISKOWE NARAZENIE NA OTOW, ARSEN I PESTYCYDY

DNA Oxidative <5 ng/mg creatinine Oxidative Stress and Stress 0(8-OHdG) Nuclear Antioxidant Status