DPN Primers are concise, highly accessible articles designed to create a bridge between psychiatry and neuroscience. Each Primer translates a single core concept across disciplines—bringing clinically-grounded psychiatric principles to basic scientists, and introducing mechanistic and methodological foundations to clinicians—so that these communities can more effectively communicate and interpret findings in a shared language. Emphasizing translational endpoints, longitudinal/continuous measurements, and objective analytics, Primers aim to create an arc where real-world symptoms connect to circuits, molecules, and computational models—thereby enabling transformational improvements in the diagnosis, treatment, and prevention of mental health conditions.