Jena, Qu et al. show that mannadjuvant, a formulation of fungal mannan and aluminum hydroxide, increases the magnitude, durability and breadth of the response elicited by mRNA-based vaccines against SARS-CoV-2 variants in mice and non-human primates.

Kerndl and colleagues identify that arginase 1-expressing monocyte-derived cells mediate arginine catabolism and detrimental effects during experimental autoimmune encephalitis-triggered neuroinflammation.

In this Resource paper, Krummel and colleagues provide analysis of 15 commonly used syngeneic mouse tumor models and compare these to the diversity of human tumor microenvironments.

Dong, Ray et al. identify salt-inducible kinases (SIKs) as potential drivers of T cell dysfunction in the immunosuppressive microenvironment of ovarian cancer.

Waterfield and colleagues report the transcription factor RUNX1 expressed in mTECs profoundly influences the diversity of thymic mimetic cells that express tissue-specific antigens.

Jena, Qu et al. show that mannadjuvant, a formulation of fungal mannan and aluminum hydroxide, increases the magnitude, durability and breadth of the response elicited by mRNA-based vaccines against SARS-CoV-2 variants in mice and non-human primates.

Dong, Ray et al. identify salt-inducible kinases (SIKs) as potential drivers of T cell dysfunction in the immunosuppressive microenvironment of ovarian cancer.

In this Resource paper, Krummel and colleagues provide analysis of 15 commonly used syngeneic mouse tumor models and compare these to the diversity of human tumor microenvironments.

Kerndl and colleagues identify that arginase 1-expressing monocyte-derived cells mediate arginine catabolism and detrimental effects during experimental autoimmune encephalitis-triggered neuroinflammation.

Salmonella-invaded intestinal stem cells activate an inflammasome-driven differentiation program toward antimicrobial Paneth cells, revealing a protective stem cell defense mechanism that helps restrict pathogen spread.