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Lineage Markers and Their Applications in Forensic DNA Analysis

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Advances in Forensic Biology and Genetics

Abstract

Lineage markers can be inherited uniparentally, such as the mitochondrial genome—from mother to child, the Y-chromosome—from father to son, or the X-chromosome when passed from mother to son, or diparentally, such as the X-chromosomes passed from mother and father to daughter. While these markers are not individualizing, they are able to determine kinship, identify missing persons through familial testing, and separate male and female DNA samples in instances of sexual assault. For this reason, these unique markers have become a standard assessment in many forensic cases. Here, we discuss the most common lineage markers, their characteristics, and their forensic value and limitations.

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Authors and Affiliations

  1. College of Biomedical and Translational Sciences, University of North Texas Health Science Center, Fort Worth, TX, USA

    Bupe Kapema, Katherine E. McBroom Henson, Isadora Mello & Roxanne R. Zascavage

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  1. Bupe Kapema
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  2. Katherine E. McBroom Henson
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  3. Isadora Mello
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  4. Roxanne R. Zascavage
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Correspondence to Roxanne R. Zascavage.

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  1. National Forensic Sciences University, New Delhi, India

    Hirak Ranjan Dash

  2. Chemistry Department and Forensic Science Program, Towson University, Towson, MD, USA

    Kelly M. Elkins

  3. Forensic Science Laboratory Directorate of Forensic Science General Directorate of Criminal Investigation and Forensic Science Ministry of Interior, Manama, Bahrain

    Noora Rashid Al-Snan

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Kapema, B., McBroom Henson, K.E., Mello, I., Zascavage, R.R. (2025). Lineage Markers and Their Applications in Forensic DNA Analysis. In: Dash, H.R., Elkins, K.M., Al-Snan, N.R. (eds) Advances in Forensic Biology and Genetics. Springer, Singapore. https://doi.org/10.1007/978-981-96-4585-5_17

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