Medical physics, Jan 19, 2018
The treatment of moving targets with scanned proton beams is challenging. For motion mitigation, ... more The treatment of moving targets with scanned proton beams is challenging. For motion mitigation, an Active Breathing Coordinator (ABC) can be used to assist breath-holding. The delivery of pencil beam scanning fields often exceeds feasible breath-hold durations, requiring high breath-hold reproducibility. We evaluated the robustness of scanned proton therapy against anatomical uncertainties when treating non-small-cell lung cancer (NSCLC) patients during ABC controlled breath-hold. Four subsequent MRIs of five healthy volunteers (3 male, 2 female, age: 25-58, BMI:19-29) were acquired under ABC controlled breath-hold during two simulated treatment fractions, providing both intra- and inter-fractional information about breath-hold reproducibility. Deformation vector fields between these MRIs were used to deform CTs of five NSCLC patients. Per patient, four or five cases with different tumor locations were modeled, simulating a total of 23 NSCLC patients. Robustly optimized (3 and 5 mm...
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Papers by David Collins