Trombin

Trombin (bahasa Inggris: Thrombin, Factor II, FIIcode: en is deprecated ) adalah sejenis glikoprotein yang dibentuk oleh dan disimpan dalam hati. Sekresi protrombin ke dalam plasma darah terjadi karena stimulasi dari tromboplastin dan ion kalsium pada proses koagulasi. Dalam proses tersebut, protrombin kemudian dikonversi menjadi trombin oleh protrombinase. Lebih lanjut, trombin akan mengkonversi fibrinogen menjadi fibrin.

F2
Struktur yang tersedia PDB Pencarian ortolog: PDBe RCSB Daftar kode ID PDB 1A2C, 1A3B, 1A3E, 1ABI, 1ABJ, 1AD8, 1AE8, 1AI8, 1AIX, 1AWF, 1AWH, 1AY6, 1B5G, 1B7X, 1BA8, 1BB0, 1BCU, 1BHX, 1BMM, 1BMN, 1BTH, 1C1U, 1C1V, 1C1W, 1C4U, 1C4V, 1C4Y, 1C5L, 1C5N, 1C5O, 1CA8, 1D3D, 1D3P, 1D3Q, 1D3T, 1D4P, 1D6W, 1D9I, 1DE7, 1DIT, 1DM4, 1DOJ, 1DWB, 1DWC, 1DWD, 1DX5, 1E0F, 1EB1, 1EOJ, 1EOL, 1FPC, 1G30, 1G32, 1G37, 1GHV, 1GHW, 1GHX, 1GHY, 1GJ4, 1GJ5, 1H8D, 1H8I, 1HAI, 1HAO, 1HAP, 1HBT, 1HLT, 1HUT, 1HXE, 1HXF, 1IHS, 1JMO, 1JOU, 1JWT, 1K21, 1K22, 1KTS, 1KTT, 1LHC, 1LHD, 1LHE, 1LHF, 1LHG, 1MH0, 1MU6, 1MU8, 1MUE, 1NM6, 1NRN, 1NRO, 1NRP, 1NRQ, 1NRR, 1NRS, 1NT1, 1NU7, 1NU9, 1NY2, 1NZQ, 1O0D, 1O2G, 1O5G, 1OOK, 1OYT, 1P8V, 1PPB, 1QBV, 1QHR, 1QJ1, 1QJ6, 1QJ7, 1QUR, 1RD3, 1RIW, 1SB1, 1SFQ, 1SG8, 1SGI, 1SHH, 1SL3, 1SR5, 1T4U, 1T4V, 1TA2, 1TA6, 1TB6, 1THP, 1THR, 1THS, 1TMB, 1TMU, 1TOM, 1TQ0, 1TQ7, 1TWX, 1UVS, 1VR1, 1VZQ, 1W7G, 1WAY, 1WBG, 1XM1, 1XMN, 1YPE, 1YPG, 1YPJ, 1YPK, 1YPL, 1YPM, 1Z71, 1Z8I, 1Z8J, 1ZGI, 1ZGV, 1ZRB, 2A0Q, 2A2X, 2A45, 2AFQ, 2ANK, 2ANM, 2B5T, 2BDY, 2BVR, 2BVS, 2BVX, 2BXT, 2BXU, 2C8Y, 2FEQ, 2FES, 2GDE, 2GP9, 2H9T, 2HGT, 2HNT, 2HPP, 2HPQ, 2HWL, 2JH0, 2JH6, 2OD3, 2PGB, 2PGQ, 2PW8, 2R2M, 2THF, 2ZFQ, 2ZFR, 2ZG0, 2ZHE, 2ZHF, 2ZHW, 2ZI2, 2ZIQ, 2ZNK, 2ZO3, 3B23, 3B9F, 3BEF, 3BEI, 3BF6, 3BIU, 3BIV, 3BV9, 3C1K, 3C27, 3D49, 3DA9, 3DD2, 3DT0, 3DUX, 3E6P, 3EE0, 3EQ0, 3F68, 3GIC, 3GIS, 3HAT, 3HKJ, 3HTC, 3JZ2, 3LDX, 3LU9, 3NXP, 3P17, 3P6Z, 3P70, 3PO1, 3QGN, 3QLP, 3QTO, 3QTV, 3QWC, 3QX5, 3R3G, 3RLW, 3RLY, 3RM0, 3RM2, 3RML, 3RMM, 3RMN, 3RMO, 3S7H, 3S7K, 3SHA, 3SHC, 3SI3, 3SI4, 3SQE, 3SQH, 3SV2, 3T5F, 3TU7, 3U69, 3U8O, 3U8R, 3U8T, 3U98, 3U9A, 3UTU, 3UWJ, 3VXE, 3VXF, 4BAH, 4BAK, 4BAM, 4BAN, 4BAO, 4BAQ, 4BOH, 4DIH, 4DII, 4DT7, 4DY7, 4E05, 4E06, 4E7R, 4H6S, 4H6T, 4HFP, 4HTC, 4THN, 5GDS, 7KME, 8KME, 1A46, 1A4W, 1A5G, 1A61, 1AFE, 1AHT, 1DWE, 1FPH, 1HAG, 1HAH, 1HDT, 1HGT, 1IHT, 1NO9, 1TBZ, 1TMT, 1UMA, 2C8W, 2C8X, 2C8Z, 2C90, 2C93, 2CF8, 2CF9, 2CN0, 2JH5, 2PKS, 2UUF, 2UUJ, 2UUK, 2V3H, 2V3O, 2ZC9, 2ZDA, 2ZDV, 2ZF0, 2ZFF, 2ZFP, 2ZGB, 2ZGX, 2ZHQ, 3DHK, 3EGK, 3JZ1, 3K65, 3PMH, 3QDZ, 4AX9, 4AYV, 4AYY, 4AZ2, 4CH2, 4CH8, 4HZH, 4I7Y, 4LOY, 4LXB, 4LZ1, 4LZ4, 4MLF, 4N3L, 4NZE, 4NZQ, 4O03, 4RKJ, 4RKO, 4RN6, 4YES, 4UD9, 4UDW, 4UE7, 4UEH, 5AF9, 5AFY, 5AFZ, 5AHG, 5CMX, 4UFD, 5EDM, 5E8E, 5EDK, 4UFE, 4UFG, 4UFF, 5A2M, 5JDU
Pengidentifikasi
Alias	F2, PT, RPRGL2, THPH1, coagulation factor II, thrombin
ID Eksternal	OMIM: 176930; MGI: 88380; HomoloGene: 426; GeneCards: F2; OMA:F2 - orthologs
Pola ekspresi RNA Bgee Manusia Tikus (ortologi) Ekspresi tertinggi di right lobe of liver Testis oosit secondary oocyte cerebellar hemisphere right hemisphere of cerebellum popliteal artery Tibial arteries fundus embrio Ekspresi tertinggi di left lobe of liver fetal liver hematopoietic progenitor cell kantung empedu Kantung kuning telur janin sexually immature organism morula primary oocyte secondary oocyte Zigot Referensi data ekspresi selengkapnya BioGPS Data ekspresi referensi lebih lanjut
Ontologi gen Fungsi molekuler calcium ion binding signaling receptor binding peptidase activity hydrolase activity growth factor activity serine-type peptidase activity thrombospondin receptor activity Ikatan protein plasma serine-type endopeptidase activity lipopolysaccharide binding heparin binding enzyme activator activity Komponen seluler extracellular exosome blood microparticle endoplasmic reticulum lumen Golgi lumen membran sel extracellular region extracellular space external side of plasma membrane collagen-containing extracellular matrix Proses biologis blood coagulation, intrinsic pathway regulation of blood coagulation positive regulation of phosphatidylinositol 3-kinase signaling positive regulation of collagen biosynthetic process multicellular organism development peptidyl-glutamic acid carboxylation acute-phase response positive regulation of reactive oxygen species metabolic process endoplasmic reticulum to Golgi vesicle-mediated transport positive regulation of cell growth cell surface receptor signaling pathway Regulasi gen positive regulation of release of sequestered calcium ion into cytosol positive regulation of cell population proliferation leukocyte migration negative regulation of fibrinolysis positive regulation of blood coagulation regulation of cytosolic calcium ion concentration response to wounding signal peptide processing positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway regulation of cell shape Hemostasis negative regulation of proteolysis negative regulation of platelet activation negative regulation of astrocyte differentiation positive regulation of protein phosphorylation Fibrinolisis Koagulasi Proteolisis platelet activation positive regulation of protein localization to nucleus positive regulation of lipid kinase activity regulation of complement activation antimicrobial humoral immune response mediated by antimicrobial peptide negative regulation of cytokine production involved in inflammatory response regulation of signaling receptor activity G protein-coupled receptor signaling pathway positive regulation of receptor signaling pathway via JAK-STAT blood coagulation, fibrin clot formation Sumber:Amigo / QuickGO
Ortologi Spesies Manusia Tikus Entrez 2147 14061 Ensembl ENSG00000180210 ENSMUSG00000027249 UniProt P00734 P19221 RefSeq (mRNA) NM_000506 NM_001311257 NM_010168 RefSeq (protein) NP_000497 NP_034298 Location (UCSC) n/a n/a PubMed search
Wikidata
Lihat/Sunting Manusia Lihat/Sunting Tikus

Vitamin K merupakan senyawa organik yang sangat penting pada sintesis protrombin.

Bacaan lanjut

• (Inggris) Prothrombin 20210 Mutation. American Heart Association