FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\RanBPMΔN
Open Close
General Information
Symbol
Dmel\RanBPMΔN
Species
D. melanogaster
Name
FlyBase ID
FBal0230248
Feature type
allele
Associated gene
Dmel\RanBPM
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description

    RanBPMΔN is a P-element excision derivative of P{RS3}RanBPMCB-6232-3 bearing a 1.448kb deletion that extends from the first intron into the second intron

    (Dansereau and Lasko, 2008)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    delins
    2R:10,430,082..10,431,250 [+]
    Comment:

    1.448kb deletion resulting from imprecise excision of P{RS3}RanBPMCB-6232-3. Some P element sequence remains (see GB:EU120026).

    (Dansereau and Lasko, 2008)
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        RanBPMΔN is a temperature-sensitive lethal allele, viable at 22[o]c and lethal at 25[o]C.

        RanBPMΔN mutants exhibit a cell-autonomous defect in cell shape and size that is most visble in the terminal filament, wherein mutant niche cells are larger and more spherical than wild-type. in addition, the organization of the filament is affected, with mutant cells often misaligned and not forming a normal single-filed array of cells.

        Stem cell division rates are unaffected in RanBPMΔN homozygous mutant ovaries compared with heterozygous controls. Stem cell loss does not occur, even over extended incubations at 20 or 25[o]C. There is a significant increase in the total number of germline stem cells attached to mutant cap cell clusters in mutant ovaries as compared with heterozygous controls. RanBPMΔN mutant cap cells support, on average, a 30% increase in total germline stem cells.RanBPMΔN mutant cap cells are significantly larger than wild-type. This increase in niche size correlates well with the increased numbr of germline stem cells that associate with cap cell clusters in the RanBPMΔN mutant.

        (Dansereau and Lasko, 2008)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        Comments
        Comments

        The following alleles can be ordered into an allelic series based on their relative strength at 25[o]C: RanBPMΔ > RanBPMf06647 > RanBPMΔN > RanBPMCB-6232-3.

        (Dansereau and Lasko, 2008)

        RanBPMΔN does not express long RanBPM but does express short RanBPM.

        (Dansereau and Lasko, 2008)
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        RanBPMΔN
        Name Synonyms
        Secondary FlyBase IDs
          References (1)