CREB1

Proteína de unión al elemento de respuesta de AMPc 1
	; Estructura tridimensional de la proteína CREB1.
Estructuras disponibles
PDB	Buscar ortólogos: PDBe, RCSB Lista de códigos PDB 1dh3
Identificadores
Símbolos	CREB1 (HGNC: 2345) CREB; MGC9284
Identificadores; externos	OMIM: 123810 ; MGI: 88494 ; HomoloGene: 3223 ; EBI: CREB1; GeneCards: Gen CREB1; UniProt: CREB1;
Locus	Cr. 2 q33.3
	Referencias: AmiGO / QuickGO
Patrón de expresión de ARNm
	Más información
Ortólogos
Humano	Ratón
1385	12912
Véase HS	Véase MM
P16220	Q01147
NM_004379	NM_001037726
NP_004370	NP_001032815
Cr. 2:; 208.39 – 208.47 Mb	Cr. 1:; 64.53 – 64.6 Mb
;
	[editar datos en Wikidata]

La proteína 1 de unión al elemento sensible al AMPc' es un factor de transcripción CREB1 (de sus siglas en inglés "CAMP responsive element binding protein 1") es una proteína humana codificada por el gen creb1. Esta proteína reconoce y une el elemento de respuesta a AMPc, que consta de una secuencia de ADN presente en multitud de promotores virales y celulares. La unión de CREB1 estimula la transcripción de los genes controlados por estos promotores.

La proteína CREB1 pertenece al conjunto de factores de transcripción CREB, los cuales son miembros a su vez de la familia de proteínas de unión a ADN con cremallera de leucina. Esta proteína se une en forma de homodímero al elemento de respuesta a AMPc, cuya secuencia se conforma de un palíndromo octamérico. La proteína es fosforilada por diversas quinasas, e induce la transcripción de genes en respuesta a estimulación hormonal de la ruta del AMPc. El gen que codifica la proteína CREB1 puede sufrir splicing alternativo, generando dos transcritos que codifican diferentes isoformas de la proteína.^[1]

Interacciones

La proteína CREB1 ha demostrado ser capaz de interaccionar con:

HTATIP^[2]
RPS6KA5^[3]^[4]
CREBBP^[5]^[6]^[7]^[8]^[9]^[10]^[11]^[12]^[13]^[14]
FHL2^[15]
FHL3^[15]
p53^[11]
CEBPB^[16]
FHL5^[15]

Véase también

CREB

Referencias

↑ «Entrez Gene: CREB1 cAMP responsive element binding protein 1».
↑ Gavaravarapu, S; Kamine J (Mar. de 2000). «Tip60 inhibits activation of CREB protein by protein kinase A». Biochem. Biophys. Res. Commun. (UNITED STATES) 269 (3): 758-66. ISSN 0006-291X. PMID 10720489. doi:10.1006/bbrc.2000.2358.
↑ Deak, M; Clifton A D, Lucocq L M, Alessi D R (Aug. de 1998). «Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB». EMBO J. (ENGLAND) 17 (15): 4426-41. ISSN 0261-4189. PMID 9687510. doi:10.1093/emboj/17.15.4426.
↑ Wang, X; Li W, Williams M, Terada N, Alessi D R, Proud C G (Aug. de 2001). «Regulation of elongation factor 2 kinase by p90(RSK1) and p70 S6 kinase». EMBO J. (England) 20 (16): 4370-9. ISSN 0261-4189. PMID 11500364. doi:10.1093/emboj/20.16.4370.
↑ Shi, Yuling; Venkataraman Sujatha L, Dodson Gerald E, Mabb Angela M, LeBlanc Scott, Tibbetts Randal S (Apr. de 2004). «Direct regulation of CREB transcriptional activity by ATM in response to genotoxic stress». Proc. Natl. Acad. Sci. U.S.A. (United States) 101 (16): 5898-903. ISSN 0027-8424. PMID 15073328. doi:10.1073/pnas.0307718101.
↑ Kim, J; Jia L, Stallcup M R, Coetzee G A (Feb. de 2005). «The role of protein kinase A pathway and cAMP responsive element-binding protein in androgen receptor-mediated transcription at the prostate-specific antigen locus». J. Mol. Endocrinol. (England) 34 (1): 107-18. ISSN 0952-5041. PMID 15691881. doi:10.1677/jme.1.01701.
↑ Shimomura, A; Ogawa Y; Kitani T; Fujisawa H; Hagiwara M (Jul. de 1996). «Calmodulin-dependent protein kinase II potentiates transcriptional activation through activating transcription factor 1 but not cAMP response element-binding protein». J. Biol. Chem. (UNITED STATES) 271 (30): 17957-60. ISSN 0021-9258. PMID 8663317.
↑ Radhakrishnan, I; Pérez-Alvarado G C, Parker D, Dyson H J, Montminy M R, Wright P E (Dec. de 1997). «Solution structure of the KIX domain of CBP bound to the transactivation domain of CREB: a model for activator:coactivator interactions». Cell (UNITED STATES) 91 (6): 741-52. ISSN 0092-8674. PMID 9413984.
↑ Sano, Y; Tokitou F; Dai P; Maekawa T; Yamamoto T; Ishii S (Oct. de 1998). «CBP alleviates the intramolecular inhibition of ATF-2 function». J. Biol. Chem. (UNITED STATES) 273 (44): 29098-105. ISSN 0021-9258. PMID 9786917.
↑ Zor, Tsaffrir; Mayr Bernhard M, Dyson H Jane, Montminy Marc R, Wright Peter E (Nov. de 2002). «Roles of phosphorylation and helix propensity in the binding of the KIX domain of CREB-binding protein by constitutive (c-Myb) and inducible (CREB) activators». J. Biol. Chem. (United States) 277 (44): 42241-8. ISSN 0021-9258. PMID 12196545. doi:10.1074/jbc.M207361200.
1 2 Giebler, H A; Lemasson I, Nyborg J K (Jul. de 2000). «p53 recruitment of CREB binding protein mediated through phosphorylated CREB: a novel pathway of tumor suppressor regulation». Mol. Cell. Biol. (UNITED STATES) 20 (13): 4849-58. ISSN 0270-7306. PMID 10848610.
↑ Zhang, Q; Vo N, Goodman R H (Jul. de 2000). «Histone binding protein RbAp48 interacts with a complex of CREB binding protein and phosphorylated CREB». Mol. Cell. Biol. (UNITED STATES) 20 (14): 4970-8. ISSN 0270-7306. PMID 10866654.
↑ Ernst, P; Wang J, Huang M, Goodman R H, Korsmeyer S J (Apr. de 2001). «MLL and CREB bind cooperatively to the nuclear coactivator CREB-binding protein». Mol. Cell. Biol. (United States) 21 (7): 2249-58. ISSN 0270-7306. PMID 11259575. doi:10.1128/MCB.21.7.2249-2258.2001.
↑ Ledo, Fran; Kremer Leonor, Mellström Britt, Naranjo Jose R (Sep. de 2002). «Ca2+-dependent block of CREB-CBP transcription by repressor DREAM». EMBO J. (England) 21 (17): 4583-92. ISSN 0261-4189. PMID 12198160.
1 2 3 Fimia, G M; De Cesare D, Sassone-Corsi P (Nov. de 2000). «A family of LIM-only transcriptional coactivators: tissue-specific expression and selective activation of CREB and CREM». Mol. Cell. Biol. (UNITED STATES) 20 (22): 8613-22. ISSN 0270-7306. PMID 11046156.
↑ Chen, Yongchang; Zhuang Shunhui, Cassenaer Stijn, Casteel Darren E, Gudi Tanima, Boss Gerry R, Pilz Renate B (Jun. de 2003). «Synergism between calcium and cyclic GMP in cyclic AMP response element-dependent transcriptional regulation requires cooperation between CREB and C/EBP-beta». Mol. Cell. Biol. (United States) 23 (12): 4066-82. ISSN 0270-7306. PMID 12773552.

Enlaces externos

En HomoloGene: CREB1

En Genome:CREB1
En MalaCards.Enfermedades que coinciden con:CREB1
En Estudio de asociación del genoma completo (GWAS) CREB1

Datos: Q21116771

[1] «Entrez Gene: CREB1 cAMP responsive element binding protein 1».

[pmid10720489-2] Gavaravarapu, S; Kamine J (Mar. de 2000). «Tip60 inhibits activation of CREB protein by protein kinase A». Biochem. Biophys. Res. Commun. (UNITED STATES) 269 (3): 758-66. ISSN 0006-291X. PMID 10720489. doi:10.1006/bbrc.2000.2358.

[pmid9687510-3] Deak, M; Clifton A D, Lucocq L M, Alessi D R (Aug. de 1998). «Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB». EMBO J. (ENGLAND) 17 (15): 4426-41. ISSN 0261-4189. PMID 9687510. doi:10.1093/emboj/17.15.4426.

[pmid11500364-4] Wang, X; Li W, Williams M, Terada N, Alessi D R, Proud C G (Aug. de 2001). «Regulation of elongation factor 2 kinase by p90(RSK1) and p70 S6 kinase». EMBO J. (England) 20 (16): 4370-9. ISSN 0261-4189. PMID 11500364. doi:10.1093/emboj/20.16.4370.

[pmid15073328-5] Shi, Yuling; Venkataraman Sujatha L, Dodson Gerald E, Mabb Angela M, LeBlanc Scott, Tibbetts Randal S (Apr. de 2004). «Direct regulation of CREB transcriptional activity by ATM in response to genotoxic stress». Proc. Natl. Acad. Sci. U.S.A. (United States) 101 (16): 5898-903. ISSN 0027-8424. PMID 15073328. doi:10.1073/pnas.0307718101.

[pmid15691881-6] Kim, J; Jia L, Stallcup M R, Coetzee G A (Feb. de 2005). «The role of protein kinase A pathway and cAMP responsive element-binding protein in androgen receptor-mediated transcription at the prostate-specific antigen locus». J. Mol. Endocrinol. (England) 34 (1): 107-18. ISSN 0952-5041. PMID 15691881. doi:10.1677/jme.1.01701.

[pmid8663317-7] Shimomura, A; Ogawa Y; Kitani T; Fujisawa H; Hagiwara M (Jul. de 1996). «Calmodulin-dependent protein kinase II potentiates transcriptional activation through activating transcription factor 1 but not cAMP response element-binding protein». J. Biol. Chem. (UNITED STATES) 271 (30): 17957-60. ISSN 0021-9258. PMID 8663317.

[pmid9413984-8] Radhakrishnan, I; Pérez-Alvarado G C, Parker D, Dyson H J, Montminy M R, Wright P E (Dec. de 1997). «Solution structure of the KIX domain of CBP bound to the transactivation domain of CREB: a model for activator:coactivator interactions». Cell (UNITED STATES) 91 (6): 741-52. ISSN 0092-8674. PMID 9413984.

[pmid9786917-9] Sano, Y; Tokitou F; Dai P; Maekawa T; Yamamoto T; Ishii S (Oct. de 1998). «CBP alleviates the intramolecular inhibition of ATF-2 function». J. Biol. Chem. (UNITED STATES) 273 (44): 29098-105. ISSN 0021-9258. PMID 9786917.

[pmid12196545-10] Zor, Tsaffrir; Mayr Bernhard M, Dyson H Jane, Montminy Marc R, Wright Peter E (Nov. de 2002). «Roles of phosphorylation and helix propensity in the binding of the KIX domain of CREB-binding protein by constitutive (c-Myb) and inducible (CREB) activators». J. Biol. Chem. (United States) 277 (44): 42241-8. ISSN 0021-9258. PMID 12196545. doi:10.1074/jbc.M207361200.

[pmid10848610-11] 1 2 Giebler, H A; Lemasson I, Nyborg J K (Jul. de 2000). «p53 recruitment of CREB binding protein mediated through phosphorylated CREB: a novel pathway of tumor suppressor regulation». Mol. Cell. Biol. (UNITED STATES) 20 (13): 4849-58. ISSN 0270-7306. PMID 10848610.

[pmid10866654-12] Zhang, Q; Vo N, Goodman R H (Jul. de 2000). «Histone binding protein RbAp48 interacts with a complex of CREB binding protein and phosphorylated CREB». Mol. Cell. Biol. (UNITED STATES) 20 (14): 4970-8. ISSN 0270-7306. PMID 10866654.

[pmid11259575-13] Ernst, P; Wang J, Huang M, Goodman R H, Korsmeyer S J (Apr. de 2001). «MLL and CREB bind cooperatively to the nuclear coactivator CREB-binding protein». Mol. Cell. Biol. (United States) 21 (7): 2249-58. ISSN 0270-7306. PMID 11259575. doi:10.1128/MCB.21.7.2249-2258.2001.

[pmid12198160-14] Ledo, Fran; Kremer Leonor, Mellström Britt, Naranjo Jose R (Sep. de 2002). «Ca2+-dependent block of CREB-CBP transcription by repressor DREAM». EMBO J. (England) 21 (17): 4583-92. ISSN 0261-4189. PMID 12198160.

[pmid11046156-15] 1 2 3 Fimia, G M; De Cesare D, Sassone-Corsi P (Nov. de 2000). «A family of LIM-only transcriptional coactivators: tissue-specific expression and selective activation of CREB and CREM». Mol. Cell. Biol. (UNITED STATES) 20 (22): 8613-22. ISSN 0270-7306. PMID 11046156.

[pmid12773552-16] Chen, Yongchang; Zhuang Shunhui, Cassenaer Stijn, Casteel Darren E, Gudi Tanima, Boss Gerry R, Pilz Renate B (Jun. de 2003). «Synergism between calcium and cyclic GMP in cyclic AMP response element-dependent transcriptional regulation requires cooperation between CREB and C/EBP-beta». Mol. Cell. Biol. (United States) 23 (12): 4066-82. ISSN 0270-7306. PMID 12773552.

[1]