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Conformationally rigid pyrazoloquinazoline α-amino acids: one- and two-photon induced fluorescence

Bell, Jonathan D., Harkiss, Alexander H., Nobis, David, Malcolm, Eilidh, Knuhtsen, Astrid, Wellaway, Christopher R., Jamieson, Andrew G. ORCID logoORCID: https://orcid.org/0000-0003-1726-7353, Magennis, Steven W. ORCID logoORCID: https://orcid.org/0000-0002-4327-8366 and Sutherland, Andrew ORCID logoORCID: https://orcid.org/0000-0001-7907-5766 (2020) Conformationally rigid pyrazoloquinazoline α-amino acids: one- and two-photon induced fluorescence. Chemical Communications, 56(12), pp. 1887-1890. (doi: 10.1039/C9CC09064A) (PMID:31956866)

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Abstract

The synthesis and photophysical properties of a new class of α-amino acid bearing a rigid pyrazoloquinazoline chromophore are described. Confromational constraint of the amino acid side-chains resulted in high emission quantum yields, while the demonstration of two-photon-induced fluorescence via near-IR excitation signifies their potential for sensitive bioimaging applications.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Magennis, Dr Steven and Knuhtsen, Dr Astrid and Harkiss, Dr Alexander and Bell, Mr Jonathan and Jamieson, Professor Andrew and Sutherland, Professor Andrew and Nobis, Mr David
Authors: Bell, J. D., Harkiss, A. H., Nobis, D., Malcolm, E., Knuhtsen, A., Wellaway, C. R., Jamieson, A. G., Magennis, S. W., and Sutherland, A.
College/School:College of Science and Engineering > School of Chemistry
Journal Name:Chemical Communications
Publisher:Royal Society of Chemistry
ISSN:1359-7345
ISSN (Online):1364-548X
Published Online:13 January 2020
Copyright Holders:Copyright © 2020 The Authors
First Published:First published in Chemical Communications 56(12):1887-1890
Publisher Policy:Reproduced under a Creative Commons License

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Project Code
Award No
Project Name
Principal Investigator
Funder's Name
Funder Ref
Lead Dept
Anderson ICASE 2015 (Selex)
Heather Lambie
IND CASE EP/N509176/1
S&E - Academic & Student Administration
Engineering and Physical Sciences Doctoral Training Grant 2012-16
Mary Beth Kneafsey
EP/K503058/1
Research and Innovation Services

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