ENZYME entry: EC 6.2.1.3

PURL: https://purl.expasy.org/enzyme/EC/6.2.1.3

Accepted Name

long-chain-fatty-acid--CoA ligase

Alternative Name(s)

acyl-activating enzyme

acyl-CoA synthetase

fatty acid thiokinase (long chain)

lignoceroyl-CoA synthase

Reaction catalysed

a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate

Comment(s)

Acts on a wide range of long-chain saturated and unsaturated fatty acids, but the enzymes from different tissues show some variation in specificity.
The liver enzyme acts on acids from C6 to C20; that from brain shows high activity up to C24.

Cross-references

Rhea expert-curated reactions

6.2.1.3

ExplorEnz

6.2.1.3

IUBMB Enzyme Nomenclature

6.2.1.3

UniProtKB/Swiss-Prot

Q2KHW5, ACBG1_BOVIN	Q96GR2, ACBG1_HUMAN	Q4R4P9, ACBG1_MACFA
Q99PU5, ACBG1_MOUSE	Q924N5, ACBG1_RAT	Q5ZKR7, ACBG2_CHICK
Q5FVE4, ACBG2_HUMAN	Q2XU92, ACBG2_MOUSE	A1L1K7, ACBG2_RAT
Q7ZYC4, ACBG2_XENLA	Q9JID6, ACSL1_CAVPO	P33121, ACSL1_HUMAN
P41216, ACSL1_MOUSE	P18163, ACSL1_RAT	O95573, ACSL3_HUMAN
Q9CZW4, ACSL3_MOUSE	Q5R668, ACSL3_PONAB	Q63151, ACSL3_RAT
O60488, ACSL4_HUMAN	Q9QUJ7, ACSL4_MOUSE	O35547, ACSL4_RAT
Q9ULC5, ACSL5_HUMAN	Q8JZR0, ACSL5_MOUSE	O88813, ACSL5_RAT
Q9UKU0, ACSL6_HUMAN	Q91WC3, ACSL6_MOUSE	P33124, ACSL6_RAT
Q9V3S9, BGM_DROME	P9WQ36, FAC13_MYCTO	P9WQ37, FAC13_MYCTU
Q7TYX8, FAC15_MYCBO	B2HGV4, FAC15_MYCMM	O53521, FAC15_MYCTU
Q7TWC5, FAC17_MYCBO	B2HHZ8, FAC17_MYCMM	O53551, FAC17_MYCTU
Q7TWB7, FAC19_MYCBO	B2HI05, FAC19_MYCMM	A0R4Q2, FAC19_MYCS2
P9WQ50, FAC19_MYCTO	P9WQ51, FAC19_MYCTU	O05307, FAC6_MYCTU
O06417, FAC8_MYCTU	Q55DR6, FCSA_DICDI	Q1ZXQ4, FCSB_DICDI
Q9V3U0, HMLL_DROME	O22898, LACS1_ARATH	Q9XIA9, LACS2_ARATH
Q9C7W4, LACS3_ARATH	Q9T0A0, LACS4_ARATH	Q9T009, LACS5_ARATH
Q8LPS1, LACS6_ARATH	Q8LKS5, LACS7_ARATH	Q9SJD4, LACS8_ARATH
Q9CAP8, LACS9_ARATH	O60135, LCF1_SCHPO	P30624, LCF1_YEAST
Q9P7D7, LCF2_SCHPO	P39518, LCF2_YEAST	P39002, LCF3_YEAST
P47912, LCF4_YEAST	P94547, LCFA_BACSU	Q8XDR6, LCFA_ECO57
P69452, LCFA_ECOL6	P69451, LCFA_ECOLI	P46450, LCFA_HAEIN
P63522, LCFA_SALTI	P63521, LCFA_SALTY	Q8ZES9, LCFA_YERPE
O07610, LCFB_BACSU	Q5SKN9, LCFCS_THET8	P44446, LCFH_HAEIN
Q3ZKN0, S27A1_BOVIN	Q6PCB7, S27A1_HUMAN	Q60714, S27A1_MOUSE
P97849, S27A1_RAT	O14975, S27A2_HUMAN	O35488, S27A2_MOUSE
P97524, S27A2_RAT	Q5K4L6, S27A3_HUMAN	O88561, S27A3_MOUSE
Q6P1M0, S27A4_HUMAN	Q4R3Y4, S27A4_MACFA	Q91VE0, S27A4_MOUSE
Q5RDY4, S27A4_PONAB	Q9Y2P5, S27A5_HUMAN	Q4LDG0, S27A5_MOUSE
Q9ES38, S27A5_RAT	Q9Y2P4, S27A6_HUMAN	E9Q9W4, S27A6_MOUSE

BRENDA

6.2.1.3

MetaCyc

6.2.1.3

KEGG Ligand Database for Enzyme Nomenclature

6.2.1.3

EC2PDB

6.2.1.3

MEDLINE

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.2.1.-
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