Expasy logo

ENZYME

ENZYME entry: EC 1.6.2.4

PURL: https://purl.expasy.org/enzyme/EC/1.6.2.4
Accepted Name
NADPH--hemoprotein reductase
Alternative Name(s)
aldehyde reductase (NADPH-dependent)
CPR
cytochrome c reductase (reduced nicotinamide adenine dinucleotide phosphate, NADPH, NADPH-dependent)
cytochrome P450 reductase
dihydroxynicotinamide adenine dinucleotide phosphate-cytochrome c reductase
FAD-cytochrome c reductase
ferrihemoprotein P-450 reductase
NADP--cytochrome c reductase
NADP--cytochrome reductase
NADPH:ferrihemoprotein oxidoreductase
NADPH:P450 reductase
NADPH--cytochrome c oxidoreductase
NADPH--cytochrome c reductase
NADPH--cytochrome P450 oxidoreductase
NADPH--cytochrome P450 reductase
NADPH-dependent cytochrome c reductase
NADPH--ferricytochrome c oxidoreductase
NADPH--ferrihemoprotein reductase
reduced nicotinamide adenine dinucleotide phosphate-cytochrome c reductase
reductase, cytochrome c (reduced nicotinamide adenine dinucleotide phosphate)
TPNH2 cytochrome c reductase
TPNH-cytochrome c reductase
Reaction catalysed
2 oxidized [cytochrome P450] + NADPH = 2 reduced [cytochrome P450] + NADP(+) + H(+)
Comment(s)
  • This enzyme catalyzes the transfer of electrons from NADPH, an obligatory two-electron donor, to microsomal P450 monooxygenases (e.g. EC 1.14.14.1) by stabilizing the one-electron reduced form of the flavin cofactors FAD and FMN.
  • It also reduces cytochrome b5 and cytochrome c.
  • The number n in the equation is 1 if the hemoprotein undergoes a 2-electron reduction, and is 2 if it undergoes a 1-electron reduction.
Cross-references
Rhea expert-curated reactions1.6.2.4
ExplorEnz1.6.2.4
IUBMB Enzyme Nomenclature1.6.2.4
UniProtKB/Swiss-Prot
A0A3G9HRC2, ALT2_ALTALQ81BF4, C102_BACCRQ2UNA2, C505_ASPOR
Q9Y8G7, C505_FUSOXA0A7T9QPQ1, CPR_PIPNIP14779, CPXB_PRIM2
A0A0C3HJL3, CYAG1_OIDMZO08336, CYPB_BACSUI7ZK32, CYPC3_ASPO3
G5EJN7, CYPD6_PHACHO08394, CYPD_BACSUA2QLV1, CYPE1_ASPNC
Q0D1W9, CYPE3_ASPTNA0A0G4P2K0, CYPE4_PENC3A0A0A2J1Z6, CYPE4_PENEN
A0A101MN42, CYPE4_PENFRG7XMT1, CYPE5_ASPKWA0A100IM63, CYPE5_ASPNG
G9MLG2, CYPP1_HYPVGR0IGL9, CYPU2_EXST2Q9HGE0, FUM6_GIBM7
Q9SB48, NCPR1_ARATHA0A2U1LIM9, NCPR1_ARTANQ7X7K8, NCPR1_ORYSJ
Q9SUM3, NCPR2_ARATHA0A2U1KZS6, NCPR2_ARTANQ0J705, NCPR2_ORYSJ
Q653S9, NCPR3_ORYSJQ4WM67, NCPR_ASPFUA2QS05, NCPR_ASPNC
Q00141, NCPR_ASPNGQ2UHA7, NCPR_ASPORQ0CMM0, NCPR_ASPTN
Q3SYT8, NCPR_BOVINP50126, NCPR_CANMAP37201, NCPR_CANTR
Q05001, NCPR_CATROP37039, NCPR_CAVPOQ55CT1, NCPR_DICDI
Q27597, NCPR_DROMEQ5BFT5, NCPR_EMENIP16435, NCPR_HUMAN
P37040, NCPR_MOUSEQ07994, NCPR_MUSDOQ9HDG2, NCPR_PHACH
P04175, NCPR_PIGP00389, NCPR_RABITP00388, NCPR_RAT
P19618, NCPR_SALTRP36587, NCPR_SCHPOC5YJG8, NCPR_SORBI
P37116, NCPR_VIGRRP16603, NCPR_YEAST
BRENDA1.6.2.4
MetaCyc1.6.2.4
KEGG Ligand Database for Enzyme Nomenclature1.6.2.4
EC2PDB1.6.2.4
MEDLINEFind literature relating to 1.6.2.4

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.6.2.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.6.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-