Oct-2

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Structures	Swiss-model
Domains	InterPro

POU domain, class 2, transcription factor 2
POU domain, class 2, transcription factor 2
Identifiers
Symbol	POU2F2
Alt. symbols	OTF2
NCBI gene	5452
HGNC	9213
OMIM	164176
RefSeq	NM_002698
UniProt	P09086
Other data
Locus	Chr. 19
Structures
Search for
Structures	Swiss-model
Domains	InterPro

POU2F2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1HDP
Identifiers
Aliases	POU2F2, OCT2, OTF2, Oct-2, POU class 2 homeobox 2
External IDs	OMIM: 164176; MGI: 101897; HomoloGene: 55674; GeneCards: POU2F2; OMA:POU2F2 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	42,196,585 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	24,879,151 bp
RNA expression pattern
	Top expressed in
	monocyte; ; buccal mucosa cell; ; granulocyte; ; lymph node; ; pancreatic ductal cell; ; paraflocculus of cerebellum; ; blood; ; vena cava; ; frontal pole; ; middle frontal gyrus;
	Top expressed in
	zygote; ; Olfactory peduncle; ; pelvic ganglion; ; secondary oocyte; ; male urethra; ; lumbar subsegment of spinal cord; ; molecular layer of cerebellar cortex; ; neural layer of retina; ; epithelium of male urethra; ; spleen;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA-binding transcription factor activity; protein domain specific binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; sequence-specific DNA binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleus; cytoplasm; nucleoplasm; intracellular membrane-bounded organelle;
Biological process	humoral immune response; regulation of transcription, DNA-templated; cell maturation; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; transcription, DNA-templated; mature B cell differentiation; transcription by RNA polymerase II; snRNA transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	5452
	18987
	ENSG00000028277
	ENSMUSG00000008496
	P09086
	Q00196
NM_001207025; NM_001207026; NM_001247994; NM_002698; NM_001393934;
	NM_001393935; NM_001393936; NM_001394376; NM_001394377; NM_001394378
	NM_001163554; NM_001163555; NM_001163556; NM_011138
	NP_001193954; NP_001193955; NP_001234923; NP_002689
	NP_001157026; NP_001157027; NP_001157028; NP_035268
	Wikidata
View/Edit Human	View/Edit Mouse

Oct-2 (octamer-binding protein 2) also known as POU domain, class 2, transcription factor 2 is a protein that in humans is encoded by the POU2F2 gene.

Oct-2 is an octamer transcription factor which is a member of the POU family.^[5]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000028277 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000008496 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Latchman DS (October 1996). "The Oct-2 transcription factor". The International Journal of Biochemistry & Cell Biology. 28 (10): 1081–3. doi:10.1016/1357-2725(96)00050-7. PMID 8930131.

External links

Octamer+Transcription+Factor-2 at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
FactorBook POU2F2

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000028277 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000008496 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Latchman_1996-5] Latchman DS (October 1996). "The Oct-2 transcription factor". The International Journal of Biochemistry & Cell Biology. 28 (10): 1081–3. doi:10.1016/1357-2725(96)00050-7. PMID 8930131.

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