Neurogenin-2

Neurogenin-2 is a protein that in humans is encoded by the NEUROG2 gene.

NEUROG2
Identifiers
Aliases	NEUROG2, Atoh4, Math4A, NGN2, bHLHa8, ngn-2, neurogenin 2
External IDs	OMIM: 606624; MGI: 109619; HomoloGene: 7633; GeneCards: NEUROG2; OMA:NEUROG2 - orthologs
Gene location (Human) Chr. Chromosome 4 (human) Band 4q25 Start 112,513,516 bp End 112,516,180 bp
Gene location (Mouse) Chr. Chromosome 3 (mouse) Band 3|3 G2 Start 127,426,784 bp End 127,429,280 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence ventricular zone gonad right hemisphere of cerebellum putamen amygdala caudate nucleus hippocampus proper prefrontal cortex anterior cingulate cortex Top expressed in ventricular zone rhombic lip fossa urethra ganglion of neuraxis ganglionic eminence pretectal area neural crest condyle zona limitans intrathalamica More reference expression data BioGPS n/a
Gene ontology Molecular function DNA binding E-box binding protein dimerization activity DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus Biological process multicellular organism development nervous system development regulation of transcription, DNA-templated positive regulation of DNA-binding transcription factor activity neuron differentiation cell differentiation transcription, DNA-templated regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 63973 11924 Ensembl ENSG00000178403 ENSMUSG00000027967 UniProt Q9H2A3 P70447 RefSeq (mRNA) NM_024019 NM_009718 RefSeq (protein) NP_076924 NP_033848 Location (UCSC) Chr 4: 112.51 – 112.52 Mb Chr 3: 127.43 – 127.43 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Neurogenin-2 is a member of the neurogenin subfamily of basic helix-loop-helix (bHLH) transcription factor genes that play an important role in neurogenesis.

It has been found to reprogram astrocytes into glutamatergic neurons when expressed.

Further reading

• Gradwohl G, Fode C, Guillemot F (November 1996). "Restricted expression of a novel murine atonal-related bHLH protein in undifferentiated neural precursors". Developmental Biology. 180 (1): 227–241. doi:10.1006/dbio.1996.0297. PMID 8948587.
• Simmons AD, Horton S, Abney AL, Johnson JE (January 2001). "Neurogenin2 expression in ventral and dorsal spinal neural tube progenitor cells is regulated by distinct enhancers". Developmental Biology. 229 (2): 327–339. doi:10.1006/dbio.2000.9984. PMID 11203697.
• Kumar M, Bagchi B, Gupta SK, Meena AS, Gressens P, Mani S (August 2007). "Neurospheres derived from human embryoid bodies treated with retinoic Acid show an increase in nestin and ngn2 expression that correlates with the proportion of tyrosine hydroxylase-positive cells". Stem Cells and Development. 16 (4): 667–681. doi:10.1089/scd.2006.0115. PMID 17784840.
• Deng S, Deng H, Le W, Xu H, Yang H, Deng X, et al. (January 2010). "Genetic analysis of the NEUROG2 gene in patients with Parkinson's disease". Neuroscience Letters. 468 (3): 195–197. doi:10.1016/j.neulet.2009.10.078. PMID 19879328. S2CID 27698762.
• Park CH, Kang JS, Yoon EH, Shim JW, Suh-Kim H, Lee SH (March 2008). "Proneural bHLH neurogenin 2 differentially regulates Nurr1-induced dopamine neuron differentiation in rat and mouse neural precursor cells in vitro". FEBS Letters. 582 (5): 537–542. Bibcode:2008FEBSL.582..537P. doi:10.1016/j.febslet.2008.01.018. PMID 18242186. S2CID 33390799.
• Fode C, Gradwohl G, Morin X, Dierich A, LeMeur M, Goridis C, et al. (March 1998). "The bHLH protein NEUROGENIN 2 is a determination factor for epibranchial placode-derived sensory neurons". Neuron. 20 (3): 483–494. doi:10.1016/S0896-6273(00)80989-7. PMID 9539123. S2CID 16790307.