Wikipedia

N-Ethylpentedrone

N-Ethylpentedrone (also known as α-ethylaminopentiophenone, α-EAPP, α-ethylamino-valerophenone, N-ethylnorpentedrone, Ethylnorpentedrone, Norpentedrone, Ethylpentedrone, and NEP) is a chemical compound and stimulant of the substituted cathinone class.[5] Since the mid-2010s, NEP has been sold online as a designer drug.[6][7] It is the N-ethyl analog of pentedrone. N-Ethylpentedrone acts as a norepinephrine-dopamine reuptake inhibitor (NDRI) without inducing monoamine release. N-Ethylpentedrone also slightly inhibits reuptake serotonin without its release.[8]

N-Ethylpentedrone
Legal status
Legal status
  • BR: Class F2 (Prohibited psychotropics)[1]
  • DE: NpSG (Industrial and scientific use only)
  • UK: Class B
  • Illegal in Japan and as of October 2025 legal,[2] but "suspicious" to produce, in China, Controlled substance in Sweden[3][4]
Identifiers
  • 2-(Ethylamino)-1-phenylpentan-1-one
CAS Number
PubChem CID
ChemSpider
UNII
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC13H19NO
Molar mass205.301 g·mol−1
3D model (JSmol)
  • CCCC(C(=O)C1=CC=CC=C1)NCC
  • InChI=InChI=1S/C13H19NO/c1-3-8-12(14-4-2)13(15)11-9-6-5-7-10-11/h5-7,9-10,12,14H,3-4,8H2,1-2H3
  • Key:QQAHEGDXEXIQPR-UHFFFAOYSA-N
edit

NEP is illegal in Japan and[9] China, and is classified as a '"potentially harmful substance"', thus, controlled.[10][11] It has also been illegal in Taiwan since February 2026.[12]

See also

edit

References

edit
  1. ↑ Anvisa (2023-07-24). "RDC Nº 804 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 804 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-07-25). Archived from the original on 2023-08-27. Retrieved 2023-08-27.
  2. ↑ Ministery of public security of the people´s republic of china (2023-07-24). "三部门联合发布最新版《非药用类麻醉药品和精神药品目录》" [The three departments jointly released the latest version of the non-pharmaceutical narcotic drugs and psychotropic drugs catalogue] (in Chinese). Ministery of public security of the people´s republic of china (published 2025-07-28). Retrieved 14 Oct 2025.
  3. ↑ "31 nya ämnen kan klassas som narkotika eller hälsofarlig vara" [31 new substances can be classified as drugs or health hazardous products] (in Swedish). Folkhälsomyndigheten. 21 June 2016.
  4. ↑ "The Swedish Governments Official List Of Narcotics".
  5. ↑ Matsuta S, Katagi M, Nishioka H, Kamata H, Sasaki K, Shima N, et al. (2014). "Structural characterization of cathinone-type designer drugs by EI mass spectrometry". Japanese Journal of Forensic Science and Technology. 19 (2): 77–89. doi:10.3408/jafst.19.77.
  6. ↑ "2-(Ethylamino)-1-phenylpentan-1-one". New Synthetic Drugs Database.
  7. ↑ Pieprzyca E, Skowronek R, Czekaj P (January 2023). "Toxicological Analysis of Cases of Mixed Poisonings with Synthetic Cathinones and Other Drugs of Abuse". Journal of Analytical Toxicology. 46 (9): 1008–1015. doi:10.1093/jat/bkab119. PMID 34849994.
  8. ↑ Duart-Castells L, Nadal-Gratacós N, Muralter M, Puster B, Berzosa X, Estrada-Tejedor R, et al. (March 2021). "Role of amino terminal substitutions in the pharmacological, rewarding and psychostimulant profiles of novel synthetic cathinones". Neuropharmacology. 186 108475. doi:10.1016/j.neuropharm.2021.108475. PMID 33529677.
  9. ↑ "指定薬物一覧" (PDF) (in Japanese). Ministry of Health, Labour and Welfare.
  10. ↑ "31 nya ämnen kan klassas som narkotika eller hälsofarlig vara" [31 new substances can be classified as drugs or health hazardous products] (in Swedish). Folkhälsomyndigheten. 21 June 2016.
  11. ↑ "The Swedish Governments Official List Of Narcotics". rkrattsbaser.gov.se. Archived from the original on 4 June 2021. Retrieved 30 June 2020.
  12. ↑ "行政院公告 中華民國115年2月13日 院臺法字第1151002189號" (PDF). 行政院公報資訊網. 13 February 2026. Retrieved 7 May 2026.
Retrieved from "https://en.wikipedia.org/w/index.php?title=N-Ethylpentedrone&oldid=1355229422"