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Draft:José M Delgado-García

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José M Delgado-García
Academic background
EducationM.D.
Ph.D.
Alma materUniversity of Seville
Academic work
InstitutionsPablo de Olavide University

José M Delgado-García is a Spanish psychiatrist and an academic. He is a professor emeritus at Pablo de Olavide University.[1]

Delgado-García's research has centred on learning, motor control, memory, neural motor systems, eye movement, and facial motor systems. Moreover, he was elected as an academic member of the 2022 International Union of Physiological Science.[2]

Education

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Delgado-García completed his bachelor's degree in medicine and surgery from the University of Seville from 1963 to 1969, followed by a doctorate in 1972 from the same institution.[3][1]

Career

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Delgado-García initially worked as an assistant professor at the University of Seville between 1970 and 1972, followed by working as the interim associate professor at the Autonomous University of Madrid between 1972 and 1975. In 1978, he was the interim aggregate professor at the University of Seville, followed by an appointment as a tenured associate professor at the same institution between 1978 and 1986. In 1986, he was promoted to a professor there. In 2000, he joined Pablo de Olavide University as a tenured full professor, and in 2015, he became an emeritus professor there.[1]

Delgado-García's administrative and professional appointments include working as a director of the Department of Physiology and Animal Biology between 1989 and 1994 at the University of Seville, as well as the principal investigator at the Andalusian Laboratory of Biology between 1997 and 2003. Additionally, between 2008 and 2015, he was director of the Animal Research Facility at Pablo de Olavide University. Moreover, since 1997, he has been the director of the division of neurosciences at Pablo de Olavide University.[1]

Research

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Delgado-García's work has focused on understanding the neural bases of behaviour,[4] learning,[5] and memory.[6] Throughout his career, he has investigated how neuronal circuits in the mammalian brain support motor functions[7] and complex cognitive processes.[8] His work has also included examining interactions between limbic structures such as the amygdala and hippocampus,[9] and he later used experimental systems[10] and highlighted how synaptic activity and synaptic plasticity, particularly long-term potentiation (LTP), contribute to the formation of associative learning and memory.[11]

A major element of Delgado-García's research has been the study of in vivo neural dynamics during learning tasks in rodents,[12] both wild-type[13] and transgenic models.[10] He has examined approaches that combine behavioural paradigms with detailed recordings of neuronal firing rates[14] and synaptic changes.[4] His work has helped clarify how different brain regions contribute to distinct types of learning, such as motor learning,[15] conditioning,[8] and has explored the cellular mechanisms of long-term potentiation[6] and other forms of plasticity.[16] In addition to neural mechanisms of learning and memory, his work extends into broader neuroscientific topics including the physiological role of neurotransmitter systems,[17] and motor control.[18]

Awards and honors

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  • 2022 – Elected Academic Member, International Union of Physiological Science[2]

Selected publications

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  • Madroñal, Noelia; Delgado-García, José M.; Fernández-Guizán, Azahara; Chatterjee, Jayanta; Köhn, Maja; Mattucci, Camilla; Jain, Apar; Tsetsenis, Theodoros; Illarionova, Anna; Grinevich, Valery; Gross, Cornelius T.; Gruart, Agnès (18 March 2016). "Rapid erasure of hippocampal memory following inhibition of dentate gyrus granule cells". Nature Communications. 7 (1). doi:10.1038/ncomms10923.
  • Ammann, C.; Marquez-Ruiz, J.; Gomez-Climent, M. A.; Delgado-Garcia, J. M.; Gruart, A. (29 June 2016). "The Motor Cortex Is Involved in the Generation of Classically Conditioned Eyelid Responses in Behaving Rabbits". Journal of Neuroscience. 36 (26): 6988–7001. doi:10.1523/JNEUROSCI.4190-15.2016.
  • Sergaki, Maria Christina; López-Ramos, Juan Carlos; Stagkourakis, Stefanos; Gruart, Agnès; Broberger, Christian; Delgado-García, José María; Ibáñez, Carlos F. (June 2017). "Compromised Survival of Cerebellar Molecular Layer Interneurons Lacking GDNF Receptors GFRα1 or RET Impairs Normal Cerebellar Motor Learning". Cell Reports. 19 (10): 1977–1986. doi:10.1016/j.celrep.2017.05.030.
  • Hernández-González, Samuel; Andreu-Sánchez, Celia; Martín-Pascual, Miguel Ángel; Gruart, Agnès; Delgado-García, José María (14 June 2017). "A Cognition-Related Neural Oscillation Pattern, Generated in the Prelimbic Cortex, Can Control Operant Learning in Rats". The Journal of Neuroscience. 37 (24): 5923–5935. doi:10.1523/JNEUROSCI.3651-16.2017.
  • Fernández-Lamo, Iván; Delgado-García, José M; Gruart, Agnès (1 March 2018). "When and Where Learning is Taking Place: Multisynaptic Changes in Strength During Different Behaviors Related to the Acquisition of an Operant Conditioning Task by Behaving Rats". Cerebral Cortex. 28 (3): 1011–1023. doi:10.1093/cercor/bhx011.
  • Andreu-Sánchez, Celia; Martín-Pascual, Miguel Ángel; Gruart, Agnès; Delgado-García, José María (December 2018). "Chaotic and Fast Audiovisuals Increase Attentional Scope but Decrease Conscious Processing". Neuroscience. 394: 83–97. doi:10.1016/j.neuroscience.2018.10.025.
  • Conde-Moro, Ana R.; Rocha-Almeida, Florbela; Sánchez-Campusano, Raudel; Delgado-García, José M.; Gruart, Agnès (December 2019). "The activity of the prelimbic cortex in rats is enhanced during the cooperative acquisition of an instrumental learning task". Progress in Neurobiology. 183: 101692. doi:10.1016/j.pneurobio.2019.101692.{{cite journal}}: CS1 maint: article number as page number (link)
  • Reus-García, M Mar; Sánchez-Campusano, Raudel; Ledderose, Julia; Dogbevia, Godwin K; Treviño, Mario; Hasan, Mazahir T; Gruart, Agnès; Delgado-García, José M (1 January 2021). "The Claustrum is Involved in Cognitive Processes Related to the Classical Conditioning of Eyelid Responses in Behaving Rabbits". Cerebral Cortex. 31 (1): 281–300. doi:10.1093/cercor/bhaa225.
  • Gruart, Agnès; Delgado-García, José M. (2 June 2023). "Neural bases of freedom and responsibility". Frontiers in Neural Circuits. 17. doi:10.3389/fncir.2023.1191996.

References

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  1. 1 2 3 4 "Jose Maria Delgado-COMPLETO - Academia.edu". www.academia.edu. Retrieved March 1, 2026.
  2. 1 2 "IUPS - Academy of Physiology".
  3. ↑ "José María Delgado García - ORCID".
  4. 1 2 Takeuchi, Tomonori; Duszkiewicz, Adrian J.; Morris, Richard G. M. (5 January 2014). "The synaptic plasticity and memory hypothesis: encoding, storage and persistence". Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 369 (1633): 3. doi:10.1098/rstb.2013.0288. ISSN 1471-2970.
  5. ↑ Oh, M. Matthew; McKay, Bridget M.; Power, John M.; Disterhoft, John F. (3 February 2009). "Learning-related postburst afterhyperpolarization reduction in CA1 pyramidal neurons is mediated by protein kinase A". Proceedings of the National Academy of Sciences of the United States of America. 106 (5): 1623. doi:10.1073/pnas.0807708106. ISSN 1091-6490.
  6. 1 2 Speed, Haley E.; Dobrunz, Lynn E. (February 2009). "Developmental changes in short-term facilitation are opposite at temporoammonic synapses compared to Schaffer collateral synapses onto CA1 pyramidal cells". Hippocampus. 19 (2): 203. doi:10.1002/hipo.20496. ISSN 1098-1063.
  7. ↑ Freeman, John H. (24 September 2015). "Cerebellar learning mechanisms". Brain Research. 1621: 264. doi:10.1016/j.brainres.2014.09.062. ISSN 1872-6240.
  8. 1 2 Figueiredo, Ítalo Leite; Frota, Priscila B.; da Cunha, Davi G.; da Silva Raposo, Ramon; Canuto, Kildere M.; de Andrade, Geanne M.; Sousa, Nuno; Moore, Sean R.; Anstead, Gregory M.; Alvarez-Leite, Jacqueline I.; Guerrant, Richard L.; Oriá, Reinaldo B. (September 2016). "Prolonged maternal separation induces undernutrition and systemic inflammation with disrupted hippocampal development in mice". Nutrition (Burbank, Los Angeles County, Calif.). 32 (9): 1019–1027. doi:10.1016/j.nut.2016.02.016. ISSN 1873-1244.
  9. ↑ Coletto, Erika; Savva, George M.; Latousakis, Dimitrios; Pontifex, Matthew; Crost, Emmanuelle H.; Vaux, Laura; Telatin, Andrea; Bergstrom, Kirk; Vauzour, David; Juge, Nathalie (26 August 2023). "Role of mucin glycosylation in the gut microbiota-brain axis of core 3 O-glycan deficient mice". Scientific Reports. 13 (1): 8. doi:10.1038/s41598-023-40497-8. ISSN 2045-2322.
  10. 1 2 Veloz Castillo, María Fernanda; Magistretti, Pierre J.; Calì, Corrado (20 August 2021). "l-Lactate: Food for Thoughts, Memory and Behavior". Metabolites. 11 (8): 5. doi:10.3390/metabo11080548. ISSN 2218-1989.
  11. ↑ Fan, Shunqin; Wang, Xijun; Gao, Ning; Wei, Songli (2023). "Electroacupuncture Pretreatment Attenuates Learning Memory Impairment Induced by Repeated Propofol Exposure and Modulates Hippocampal Synaptic Plasticity in Rats". Journal of Inflammation Research. 16: 4570. doi:10.2147/JIR.S427925. ISSN 1178-7031.
  12. ↑ Minichiello, Liliana (December 2009). "TrkB signalling pathways in LTP and learning". Nature Reviews Neuroscience. 10 (12): 853. doi:10.1038/nrn2738. ISSN 1471-0048.
  13. ↑ Pereyra, Guadalupe; Mateo, María Inés; Miaja, Pablo; Martin-Bermejo, María Jesús; Martinez-Baños, Marcos; Klaassen, Remco; Gruart, Agnès; Rueda-Carrasco, Javier; Fernández-Rodrigo, Alba; López-Merino, Esperanza; Esteve, Pilar; Esteban, José A.; Smit, August B.; Delgado-García, José M.; Bovolenta, Paola (22 April 2025). "SFRP1 upregulation causes hippocampal synaptic dysfunction and memory impairment". Cell Reports. 44 (4): 6. doi:10.1016/j.celrep.2025.115535. ISSN 2211-1247.
  14. ↑ Whitlock, Jonathan R.; Heynen, Arnold J.; Shuler, Marshall G.; Bear, Mark F. (25 August 2006). "Learning induces long-term potentiation in the hippocampus". Science. 313 (5790): 1097. doi:10.1126/science.1128134. ISSN 1095-9203.
  15. ↑ Manto, Mario; Bower, James M.; Conforto, Adriana Bastos; Delgado-García, José M.; da Guarda, Suzete Nascimento Farias; Gerwig, Marcus; Habas, Christophe; Hagura, Nobuhiro; Ivry, Richard B.; Mariën, Peter; Molinari, Marco; Naito, Eiichi; Nowak, Dennis A.; Oulad Ben Taib, Nordeyn; Pelisson, Denis; Tesche, Claudia D.; Tilikete, Caroline; Timmann, Dagmar (June 2012). "Consensus paper: roles of the cerebellum in motor control--the diversity of ideas on cerebellar involvement in movement". Cerebellum. 11 (2): 463. doi:10.1007/s12311-011-0331-9. ISSN 1473-4230.
  16. ↑ Oh, M. Matthew; McKay, Bridget M.; Power, John M.; Disterhoft, John F. (3 February 2009). "Learning-related postburst afterhyperpolarization reduction in CA1 pyramidal neurons is mediated by protein kinase A". Proceedings of the National Academy of Sciences of the United States of America. 106 (5): 1623. doi:10.1073/pnas.0807708106. ISSN 1091-6490.
  17. ↑ Wei, Catherine J.; Li, Wei; Chen, Jiang-Fan (1 May 2011). "Normal and abnormal functions of adenosine receptors in the central nervous system revealed by genetic knockout studies". Biochimica et Biophysica Acta (BBA) - Biomembranes. 1808 (5): 1364. doi:10.1016/j.bbamem.2010.12.018. ISSN 0005-2736.
  18. ↑ López-Ramos, Juan C.; Houdek, Zbynek; Cendelín, Jan; Vožeh, Frantisek; Delgado-García, José M. (16 July 2018). "Timing correlations between cerebellar interpositus neuronal firing and classically conditioned eyelid responses in wild-type and Lurcher mice". Scientific Reports. 8 (1): 10697. doi:10.1038/s41598-018-29000-w. ISSN 2045-2322.
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