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IgA vasculitis in a patient with ulcerative colitis under infliximab: drug-induced or genetic?

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Abstract

We present the case of a 17-year-old male patient with ulcerative colitis (UC) under infliximab therapy and a family history of IgA vasculitis (IgAV). During a maintenance infliximab session, he developed palpable purpura, abdominal pain, and hematochezia. Computed tomography and endoscopy revealed findings compatible with gastrointestinal manifestations of IgAV. He was successfully treated by intravenous prednisolone and did not develop recurrence of IgAV during subsequent infliximab infusions.

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Authors and Affiliations

  1. Division of Gastroenterology, Department of Internal Medicine, School of Medicine, Iwate Medical University, Morioka, Japan

    Jun Urushikubo, Shunichi Yanai, Shotaro Nakamura, Yosuke Toya, Kensuke Asakura, Takahiro Gonai & Takayuki Matsumoto

  2. Division of Molecular Diagnostic Pathology, Department of Pathology, School of Medicine, Iwate Medical University, Morioka, Japan

    Makoto Eizuka, Noriyuki Uesugi & Tamotsu Sugai

Authors
  1. Jun Urushikubo
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  2. Shunichi Yanai
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  3. Shotaro Nakamura
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  4. Yosuke Toya
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  6. Takahiro Gonai
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  7. Makoto Eizuka
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  8. Noriyuki Uesugi
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  9. Tamotsu Sugai
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  10. Takayuki Matsumoto
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Correspondence to Jun Urushikubo.

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Conflict of interest

Jun Urushikubo, Shunichi Yanai, Shotaro Nakamura, Yosuke Toya, Kensuke Asakura, Takahiro Gonai, Makoto Eizuka, Noriyuki Uesugi, Tamotsu Sugai and Takayuki Matsumoto declare that they have no conflict of interest.

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All procedures followed have been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments.

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Informed consent was obtained from all patients for being included in the study.

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Urushikubo, J., Yanai, S., Nakamura, S. et al. IgA vasculitis in a patient with ulcerative colitis under infliximab: drug-induced or genetic?. Clin J Gastroenterol 14, 198–203 (2021). https://doi.org/10.1007/s12328-020-01280-8

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  • DOI: https://doi.org/10.1007/s12328-020-01280-8

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