Abstract
HuLy-m3 is an M r 47 000 pan-leukocyte antigen detected by the monoclonal antibody (mAb) 5-4.8. This report describes the isolation and analysis of a cDNA clone encoding HuLy-m3. Serological analysis demonstrated that antibodies of the CD48 cluster also reacted with transfected cells expressing HuLy-m3. The DNA sequence of the clone suggests linkage to the cell membrane through a glycosyl phosphatidylinositol tail and this was verified experimentally. Sequence similarity with the human B-cell activation antigen Blast-1 was noted.
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The nucleotide sequence data reported in this paper have been submitted to the GenBank nucleotide sequence database and have been assigned the accession number M 59904.
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Vaughan, H.A., Henning, M.M., Purcell, D.F.J. et al. The isolation of cDNA clones for CD48. Immunogenetics 33, 113–117 (1991). https://doi.org/10.1007/BF00210824
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DOI: https://doi.org/10.1007/BF00210824