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File:Schematic diagram of Foot-and-mouth disease virus (FMDV) genome, processing of viral polypeptide and conformations of the structural proteins.webp

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Schematic diagram of Foot-and-mouth disease virus (FMDV) genome, processing of viral polypeptide and conformations of the structural proteins.

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English: Schematic diagram of FMDV genome, processing of viral polypeptide and conformations of the structural proteins. FMDV genome RNA contains a single open reading frame (ORF) of about 7 kb with two alternative initiation sites. The ORF is flanked by a long 5ʹ-untranslated region (5ʹ-UTR) and a short 3ʹ-UTR. 3B (VPg) is covalently bound to its 5ʹ end. The ORF region is generally divided into four functional areas (L, P1, P2 and P3) due to the different functions of mature polypeptides. ORF-encoded polyprotein is processed into four products, Lpro, P1-2A, 2BC and P3 by Lpro, 2A and 3Cpro. The precursors P1-2A, 2BC and P3 are further processed into mature viral proteins and some cleavage intermediates with relative stability, such as VP0 or 1AB, 3ABC, 3BCD, 3AB, and 3CD by 3Cpro. Structural proteins form the biological protomer and viral capsid
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Source https://virologyj.biomedcentral.com/articles/10.1186/s12985-016-0561-z
Author Yuan Gao, Shi-Qi Sun and Hui-Chen Guo

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