A 3D bioprinting system to produce human-scale tissue constructs with structural integrity

@article{Kang2016A3B,
  title={A 3D bioprinting system to produce human-scale tissue constructs with structural integrity},
  author={Hyun-Wook Kang and Sang Jin Lee and In Kap Ko and Carlos Kengla and James J. Yoo and Anthony Atala},
  journal={Nature Biotechnology},
  year={2016},
  volume={34},
  pages={312-319},
  url={https://api.semanticscholar.org/CorpusID:9073831}
}
An integrated tissue–organ printer (ITOP) that can fabricate stable, human-scale tissue constructs of any shape is presented and the incorporation of microchannels into the tissue constructs facilitates diffusion of nutrients to printed cells, thereby overcoming the diffusion limit of 100–200 μm for cell survival in engineered tissues.
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