Promoter methylation status of hMLH1, hMSH2, and MGMT genes in colorectal cancer associated with adenoma–carcinoma sequence

@article{Lee2008PromoterMS,
  title={Promoter methylation status of hMLH1, hMSH2, and MGMT genes in colorectal cancer associated with adenoma–carcinoma sequence},
  author={Kyung‐Hwa Lee and Ji-Shin Lee and Jong Hee Nam and Chan Choi and Min‐Cheol Lee and Chang‐soo Park and Sang Woo Juhng and Jae-Hyuk Lee},
  journal={Langenbeck's Archives of Surgery},
  year={2008},
  volume={396},
  pages={1017-1026},
  url={https://api.semanticscholar.org/CorpusID:8069716}
}
Data suggest that CpG island methylation in hMSH2 and MGMT, but not hMLH1, is closely related to carcinogenesis in colorectal carcinomas presenting with a conventional adenoma–carcinoma sequence, and may have clinical significance in the evaluation of colon cancer patients and in tumor-specific management of the disease.
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44 References

Promoter methylation status of hMLH1, MGMT, and CDKN2A/p16 in colorectal adenomas.

Methylation analysis of hMLH1, CDKN2A/p16, and MGMT revealed specific methylation profiles for tubular adenomas, tubulovillous/villous adenoma, and colorectal cancers, supporting the use of these alterations in assessment of coloreCTal tumorigenesis.

Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma.

The results suggest that microsatellite instability in sporadic colorectal cancer often results from epigenetic inactivation of hMLH1 in association with DNA methylation.

Support for hMLH1 and MGMT silencing as a mechanism of tumorigenesis in the hyperplastic-adenoma-carcinoma (serrated) carcinogenic pathway in the colon.

Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is a common event in primary human neoplasia.

The presence of aberrant hypermethylation was associated with loss of MGMT protein, in contrast to retention of protein in the majority of tumors without aberrantHypermethylation, suggesting that epigenetic inactivation of MG MT plays an important role in primary human neoplasia.

Promoter hypermethylation of tumor‐related genes in the progression of colorectal neoplasia

The study demonstrated the early and specific involvement of promoter hypermethylation in the colorectal adenoma‐carcinoma sequence and there was no significant association between promoter hyperethylation and other clinicopathologic characteristics of cancer.

Promoter methylation of P16, RARβ, E-cadherin, cyclin A1 and cytoglobin in oral cancer: quantitative evaluation using pyrosequencing

This data demonstrated p16 promoter methylation in a highly tumour specific pattern and Cytoglobin is a novel candidate tumour suppressor gene highly methylated in upper aero-digestive tract squamous cancer.

Gene methylation profiles of normal mucosa, and benign and malignant colorectal tumors identify early onset markers

Methylated ADAMTS1, MGMT, and MAL are suitable as markers for early tumor detection, and MSI and mutated BRAF were associated with samples harboring hypermethylation of several target genes.

CpG island methylation of genes accumulates during the adenoma progression step of the multistep pathogenesis of colorectal cancer

The aberrant methylation of genes appears to increase most significantly during the progression of early adenomas to advancedAdenomas, and the frequency of specific gene methylation at the different steps of the adenoma‐carcinoma progression sequence varies in a gene‐specific fashion.

Aberrantly methylated CDKN2A, MGMT, and MLH1 in colon polyps and in fecal DNA from patients with colorectal polyps.

Results show that aberrant methylated genes can be detected frequently in sporadic colon polyps and that they can be detect in fecal DNA.

Biallelic inactivation of hMLH1 by epigenetic gene silencing, a novel mechanism causing human MSI cancers.

Mutations of DNA mismatch repair genes, including the hMLH1 gene, have been linked to human colon and other cancers in which defective DNA repair is evidenced by the associated instability of DNA…
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