Molecular and biological characterization of a murine ligand for CD40

@article{Armitage1992MolecularAB,
  title={Molecular and biological characterization of a murine ligand for CD40},
  author={Richard J. Armitage and William Christian Fanslow and Laura D. Strockbine and Timothy A. Sato and Ky N. Clifford and Brian M. Macduff and Dirk M. Anderson and Steven D. Gimpel and Terri Davis‐Smith and Charles R. Maliszewski and Edward A. Clark and Craig A. Smith and Kenneth H. Grabstein and David J. Cosman and Melanie K. Spriggs},
  journal={Nature},
  year={1992},
  volume={357},
  pages={80-82},
  url={https://api.semanticscholar.org/CorpusID:4336943}
}
The cloning of a ligand for CD40 that is expressed on the cell surface of activated T cells and mediates B-cell proliferation in the absence of co-stimulus, as well as IgE production in the presence of interIeukin-4 is reported.
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The biology of the human ligand for CD40

Functional data such as these led to the search for studies using monoclonal antibodies to CD40 which indicated a diverse array of biological activities occurs as a result of signaling through CD40.

The CD40 antigen and its ligand.

As other members of the tumor necrosis factor receptor family have been shown to bind several ligands, it is possible that CD40 may bind other ligands that may trigger CD40 on different cell types such as hematopoietic cells or epithelial cells.

Recombinant human CD40 ligand stimulates B cell proliferation and immunoglobulin E secretion

Northern blot and FACS analyses suggest that the hCD40-L is restricted in its expression to T lymphocytes, and that it is most abundant on the CD4+ T cell subpopulation.

Recombinant Human CD 40 Ligand Stimulates B Cell Proliferation and Immunoglobulln E Secretion

Northern blot and FACS | analyses suggest that the hCD40-L is restricted in its expression to T lymphocytes, and that it is most abundant on the CD4 + T cell subpopulation.

Expression and release of CD27 in human B-cell malignancies.

A strong correlation between s CD27 levels in the serum and tumor load is found, indicating that sCD27 can be used as a disease-marker in patients with acute and chronic B-cell malignancies.

A novel function of CD40: induction of cell death in transformed cells

It is shown that CD40 ligation induces apoptotic cell death in transformed cells of mesenchymal and epithelial origin and seems to use a preformed signaling pathway since it occurs even when protein synthesis is blocked.

Heteromultimeric Complexes of CD40 Ligand Are Present on the Cell Surface of Human T Lymphocytes*

It is reported that, under normal physiological conditions, CD40L molecules exist as heteromultimeric complexes, which are present on the cell surface of T lymphocytes and are capable of interacting with CD40 molecule.

Conservation of biological properties of the CD40 ligand, CD154 in a non-mammalian vertebrate.

2 A crystal structure of an extracellular fragment of human CD40 ligand.

Molecular and biological characterization of a ligand for CD27 defines a new family of cytokines with homology to tumor necrosis factor

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24 References

The human B lymphocyte and carcinoma antigen, CDw40, is a phosphoprotein involved in growth signal transduction.

It is demonstrated that signaling through this Ag is dependent on its aggregation on the cell surface, and monovalent antibody fragments were relatively inefficient in this respect but effectively blocked stimulation by intact antibody.

CD40 signaling activates CD11a/CD18 (LFA-1)-mediated adhesion in B cells.

Signaling through CD40, elicited by cross-linking the CD40 protein on the cell surface, activates the CD18/intercellular adhesion molecule adhesion system and augmented the ability of dense B cells to stimulate the proliferation of allogeneic T cells via a CD18-dependent process.

Biochemical characteristics and partial amino acid sequence of the receptor-like human B cell and carcinoma antigen CDw40.

Results show that CDw40 derived from B cells or from TCC cells are the same or closely related molecules, and Comparisons of the amino acid sequence and biochemical characteristics ofCDw40 with proteins having receptor functions indicated a close structural resemblance of CDw 40 to the nerve growth factor-receptor.

A B‐lymphocyte activation molecule related to the nerve growth factor receptor and induced by cytokines in carcinomas.

The sequence of a cDNA clone encoding Bp50 was analyzed and an extensive homology with the nerve growth factor receptor was found, suggesting a role for the molecule in the development of carcinomas at sites of chronic inflammation.

Stimulation of protein tyrosine phosphorylation, phosphoinositide turnover, and multiple previously unidentified serine/threonine-specific protein kinases by the Pan-B-cell receptor CD40/Bp50 at discrete developmental stages of human B-cell ontogeny.

Long-term human B cell lines dependent on interleukin-4 and antibody to CD40.

In combination with interleukin-4, factor-dependent long-term normal human B cell lines were generated that were consistently negative for Epstein-Barr viral infection and cross-linking of CD40 is likely to represent an important phenomenon in the clonal expansion of B cells.

Activation of human B cells mediated through two distinct cell surface differentiation antigens, Bp35 and Bp50.

The results suggest that the Bp35 and Bp50 surface molecules function in the regulatory control of B-cell activation and progression through the cell cycle.

A novel IL‐1 receptor, cloned from B cells by mammalian expression, is expressed in many cell types.

The use of an improved expression cloning method is used to isolate human and murine cDNA clones encoding a second type of IL‐1 receptor (type II receptor), which appears to be well conserved in evolution and map to the same chromosomal location.

Molecular cloning and expression of a receptor for human tumor necrosis factor

Molecular cloning and expression of the human 55 kd tumor necrosis factor receptor

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