Estrogens and the lower urinary tract

@article{Robinson2011EstrogensAT,
  title={Estrogens and the lower urinary tract},
  author={Dudley Robinson and Linda D. Cardozo},
  journal={Neurourology and Urodynamics},
  year={2011},
  volume={30},
  url={https://api.semanticscholar.org/CorpusID:36951754}
}
Although to date the role of oestrogen replacement therapy in the management of postmenopausal urinary incontinence remains controversial its use in the Management of women complaining of urogenital atrophy is now well established.
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102 Citations
Highly Influential Citations
4
Background Citations
40
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102 Citations

Stress urinary incontinence and endogenous sex steroids in postmenopausal women

This study aimed to elucidate the possible relationship between endogenous circulating estrogens and the onset and development of stress urinary incontinence (SUI).

High luteinizing hormone weakens urinary continence mechanisms in association with prostaglandin E2 elevation in a postmenopausal rat model

To explore the role of luteinizing hormone (LH) in the urinary continence mechanism, urethral function was investigated using a postmenopausal rat model with high serum LH concentrations and a gonadotropin releasing hormone (GnRH) antagonist to lower LH concentrations.

Urologic perspective of genitourinary syndrome of menopause

The main pathophysiology mechanisms of GSM affecting the lower urinary tract and the manifestations and treatment options for lower urinary tract dysfunction in GSM are described.

An Investigation of Lower Urinary Tract Symptoms in Women Aged 40 and Over

The objective of this study was to determine lower urinary tract symptoms (LUTS) and associated risk factors in women aged 40 years and over.

Changes of Urinary Tract after Menopause and Effectiveness of Menopausal Hormone Replacement Therapy

The current issues on the relationship among urinary tract and sex hormone and menopause, and the effectiveness of menopausal hormone replacement therapy for the treatment of overactive bladders, stress urinary tract incontinence and recurrent urinary tract infection are reviewed.

New approaches to treat women’s urogenital problems

A clinical expansion protocol of mesenchymal stem cells (MSCs) is developed that shows that MSCs can be injected into the defective sphincter urethrae in order to improve its function by restoring the structure and, eventually, maintaining the continence.

Bladder Dysfunction and Urinary Incontinence After the Menopause: Hormones, Drugs, or Surgery?

It seems that there are no beneficial effects in using estrogens therapy, both local and systemic, on stress urinary incontinence, and lifestyle changes and bladder retraining are recommended as first line therapy for overactive bladder symptoms.

[Urinary incontinence and menopause].

The mysteries of menopause and urogynecologic health: clinical and scientific gaps

This review summarizes the epidemiology of the individual PFDs with particular attention to the understanding of the relationship between each PFD and menopausal estrogen levels, and the gaps in science and clinical care that affect menopausal women.

Genitourinary Syndrome of Menopause

The gynecologist is in a unique position to sensitively discuss the symptoms of genitourinary syndrome, advise, educate and treat appropriately, providing long-term follow-up.
...

38 References

The Effects of Estrogens and Gestagens on the Urethral Pressure Profile in Urinary Continent and Stress Incontinent Women

The present investigation was performed to study the urodynamic effects of hormones on the lower urinary tract in women by randomly giving E2 and E3 orally in doses of 4–8 mg per day for 3 weeks.

Oestriol in the treatment of postmenopausal urgency: a multicentre study.

The effect of oestradiol on vaginal collagen metabolism in postmenopausal women with genuine stress incontinence

To determine whether oestrogen replacement will produce an improvement in the quantity, or quality, of pelvic collagen in postmenopausal women, a large number of women will undergo surgery.

Low dose oral estriol treatment in elderly women with urogenital infections.

Endocrine status and markers of collagen synthesis and degradation in serum and urogenital tissue from women with and without stress urinary incontinence

To investigate possible differences in androgen/estrogen status between patients with stress urinary incontinence (SUI) and healthy women's and to study possible associations between circulating…

Low Dose Oral Estriol Treatment in Elderly Women with Urogenital Infections

Forty‐one female geriatric in‐patients with recurrent urogenital infections took part in a cross‐over intervention study with oral estriol as an alternative to antibiotics.

Control of recurrent lower urinary tract infection in the postmenopausal woman.

Low dose oestrogen prophylaxis for recurrent urinary tract infections in elderly women.

Efficacy of Estrogen Supplementation in the Treatment of Urinary Incontinence

Oestrogen therapy for urinary incontinence in post-menopausal women.

There was little evidence from the trials on the period after oestrogen treatment had finished and none about long-term effects, but there was some evidence that oestrogens used locally (for example vaginal creams or tablets) may improve incontinence, but systemic hormone replacement therapy, using conjugated equine Oestrogen, may makeincontinence worse.

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