Steroid-hormone rapid actions, membrane receptors and a conformational ensemble model

@article{Norman2004SteroidhormoneRA,
  title={Steroid-hormone rapid actions, membrane receptors and a conformational ensemble model},
  author={Anthony W. Norman and Mathew T. Mizwicki and Derek P. G. Norman},
  journal={Nature Reviews Drug Discovery},
  year={2004},
  volume={3},
  pages={27-41},
  url={https://api.semanticscholar.org/CorpusID:17487277}
}
This review summarizes the current knowledge of membrane-associated steroid receptors, as well as details of structure–function relationships between steroid hormones and the ligand-binding domains of their nuclear and membrane- associated receptors.
View on Springer Nature
ncbi.nlm.nih.gov
561 Citations
Highly Influential Citations
12
Background Citations
166
Methods Citations
6
Results Citations
2

561 Citations

Rapid steroid hormone actions via membrane receptors.

Rapid steroid hormone actions initiated at the cell surface and the receptors that mediate them with an emphasis on recent progress in fish models.

Direct binding and activation of protein kinase C isoforms by steroid hormones

Regulation of signal transduction pathways by estrogen and progesterone.

The nature of the receptors that mediate rapid signaling actions of estrogen and progesterone are reviewed, the signaling molecules and pathways involved, the mechanisms by which receptors couple with components of signaling complexes and trigger responses, and the target tissues and cell functions regulated by this mode of steroid hormone action are described.

Non-genomic steroid hormone effects: Membrane or intracellular receptors?

Nuclear receptors: Genomic and non-genomic effects converge

Novel findings are discussed indicating transcriptional regulation through ligand-dependent and -independent crosstalk of nuclear receptors with β-catenin or VDR-interacting repressor (VDIR), in which the non-genomic effects constitute signaling pathways required for the effects at the genome level.

Progestin, estrogen and androgen G-protein coupled receptors in fish gonads

MSK1 and Nuclear Receptors Signaling

The recent insights concerning the crosstalk between the genomic and non‐genomic actions of NRs are reviewed, focusing on the mechanisms of MSK1 activation and influence on NR‐target genes transcriptional regulation.

Receptors for steroid hormones: membrane-associated and nuclear forms

It is concluded that both rapid (membrane-initiated) actions, as well as regulation of gene transcription, are necessary to explain the complex actions of steroid hormones on target cells.

Steroid receptors and their ligands: effects on male gamete functions.

...

126 References

Membrane-initiated steroid actions and the proteins that mediate them.

The integration of membrane-initiated effects with genomic mechanisms results in the complete cellular response to steroids, including steroid-dependent tumor growth, developmental and therapeutic apoptosis, and the actions of endocrine disrupters.

Rapid Actions of Steroid Receptors in Cellular Signaling Pathways

Identification of interaction domains on the classical steroid receptors involved in the rapid effects, and separation of this function from the genomic action of these receptors, should pave the way to a better understanding of the rapid action of steroid hormones.

Multiple actions of steroid hormones--a focus on rapid, nongenomic effects.

Sex hormone-binding globulin mediates steroid hormone signal transduction at the plasma membrane

Cellular functions of plasma membrane estrogen receptors

Orphan nuclear receptors: shifting endocrinology into reverse.

A "reverse endocrinology" strategy has resulted in the discovery of unanticipated nuclear signaling pathways for retinoids, fatty acids, eicosanoids, and steroids with important physiological and pharmacological ramifications.

Functional studies of corticosterone receptors in neuronal membranes.

Evidence that some physiological and behavioral responses to steroid hormones use membrane-associated receptors in neuronal membranes is reviewed, highlighting research with an amphibian model, Taricha granulosa, and indicating two types of membrane- associated steroid receptors--ligand-gated ion channels and G-protein coupled receptors.

Genomics versus orphan nuclear receptors--a half-time report.

The significant progress that has been made in the functional analysis of more than half of the nuclear receptor gene family provides an opportunity to review the impact of genomics in this endeavor.

Cloning, expression, and characterization of a membrane progestin receptor and evidence it is an intermediary in meiotic maturation of fish oocytes

Cloning of a cDNA from spotted seatrout ovaries encoding a protein that satisfies the following seven criteria for its designation as a steroid membrane receptor suggests the fish protein is a membrane progestin receptor mediating a “nonclassical” action of progestins to induce oocyte maturation in fish.

A mathematical model describing the subcellular localization of non-membrane bound steroid, seco-steroid and thyronine receptors.

...

Related Papers

Showing 1 through 3 of 0 Related Papers