Heat Shock Factors at a Crossroad between Stress and Development

@article{kerfelt2007HeatSF,
  title={Heat Shock Factors at a Crossroad between Stress and Development},
  author={Malin {\AA}kerfelt and Diane Trouillet and Val{\'e}rie Mezger and Lea Sistonen},
  journal={Annals of the New York Academy of Sciences},
  year={2007},
  volume={1113},
  url={https://api.semanticscholar.org/CorpusID:10885427}
}
This chapter presents the different roles of the mammalian HSFs as regulators of cellular stress and developmental processes, highlighting the interaction between different HSFs and discussing the discoveries of novel target genes in addition to the classical Hsps.
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203 Citations
Highly Influential Citations
13
Background Citations
83
Methods Citations
2
Results Citations
1

203 Citations

Implication of Heat Shock Factors in Tumorigenesis: Therapeutical Potential

The different physiological roles of HSFs as well as the recent discoveries in term of non-cogenic potential of these HSFs, more specifically associated to the activation of “non-classical” HSF target genes are described.

The heat shock response and small molecule regulators.

Roles of heat shock factor 1 and 2 in response to proteasome inhibition: consequence on p53 stability

This study points a new role for HSF2 in the regulation of protein degradation and suggests that pan-HSF inhibitors could be valuable tools to reduce chemoresistance to proteasome inhibition observed in cancer therapy.

The heat shock factor family and adaptation to proteotoxic stress

The heat shock response regulated by the HSF family should consist of the induction of classical as well as of nonclassical heat shock genes, both of which might be required to maintain protein homeostasis.

Identification of Heat Shock Factor Binding Sites in the Drosophila Genome

Interestingly, the binding of HSF also coincides with puff regression at some sites, and two such sites contain the major developmentally regulated genes Eip74 and Eip75: key regulators in the response to 20-hydroxyecdysone, the main hormone responsible for the temporal coordination of post-embryonic development in Drosophila.

Involvement of the heat shock response (HSR) regulatory pathway in cadmium-elicited cerebral damage

Exposure to cadmium (Cd) triggers the heat shock response (HSR) by activating heat shock transcription factors (HSFs) and subsequent induction of major heat shock proteins (notably, HSP60, HSP70, and HSP90).

Heat shock factors: integrators of cell stress, development and lifespan

These unexpected observations have uncovered complex layers of post-translational regulation of HSFs that integrate the metabolic state of the cell with stress biology, and in doing so control fundamental aspects of the health of the proteome and ageing.

The Heat Shock Response and the Stress of Misfolded Proteins

Heat Shock Factors in the European Eel: Gene Characterization and Expression Response to Different Environmental Conditions and to Induced Sexual Maturation

Analysis of the HSF gene family in the European eel under different environmental conditions and during testis maturation indicates that HSF genes are potentially implicated in the response to environmental changes perception and during gonadal maturation.

An Atypical Unfolded Protein Response in Heat Shocked Cells

The initial step in the UPR, synthesis of transcription factors, is activated by heat stress but the second step, transcriptional transactivation by these factors is blocked and these pathways of the U PR are thus not productive.
...

61 References

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  • Biology, Medicine
    Cell stress & chaperones
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It is concluded that 1) constitutive and inducibly expressed HSPs exhibit distinct physiological functions for cellular maintenance and adaptation, respectively, and 2) other mammalian HSFs or distinct evolutionarily conserved stress response pathways do not compensate for HSF1 in the physiological response to heat shock.

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Heat Shock Transcription Factor 1 Is Involved in Quality-Control Mechanisms in Male Germ Cells1

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This chapter examines the established stress-related functions and prospect the intriguing role of HSF 1 as a developmental coordinator, involving a monomer-to-trimer transition, nuclear accumulation and extensive posttranslational modifications.

HSF1 is required for extra‐embryonic development, postnatal growth and protection during inflammatory responses in mice

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