{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T18:03:47Z","timestamp":1764698627484,"version":"3.41.0"},"reference-count":89,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2004,9,1]],"date-time":"2004-09-01T00:00:00Z","timestamp":1093996800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2004,9,1]],"date-time":"2004-09-01T00:00:00Z","timestamp":1093996800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Comput Neurosci"],"published-print":{"date-parts":[[2004,9]]},"DOI":"10.1023\/b:jcns.0000037678.26155.b5","type":"journal-article","created":{"date-parts":[[2004,8,12]],"date-time":"2004-08-12T12:55:35Z","timestamp":1092315335000},"page":"149-164","source":"Crossref","is-referenced-by-count":36,"title":["A Biophysical Model of Synaptic Delay Learning and Temporal Pattern Recognition in a Cerebellar Purkinje Cell"],"prefix":"10.1007","volume":"17","author":[{"given":"Volker","family":"Steuber","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Willshaw","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"5276998_CR1","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1113\/jphysiol.1979.sp012745","volume":"289","author":"DM Armstrong","year":"1979","unstructured":"Armstrong DM, Rawson JA (1979) Activity patterns of cerebellar cortical neurones and climbing fibre afferents in the awake cat. J. Physiol 289: 425\u2013448.","journal-title":"J. Physiol"},{"key":"5276998_CR2","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/0028-3908(93)90124-L","volume":"32","author":"AM Batchelor","year":"1993","unstructured":"Batchelor AM, Garthwaite J (1993)Novel synaptic potentials in cerebellar Purkinje cells: Probable mediation by metabotropic glutamate receptors. Neuropharmacology 32: 11\u201320.","journal-title":"Neuropharmacology"},{"key":"5276998_CR3","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1038\/385074a0","volume":"385","author":"AM Batchelor","year":"1997","unstructured":"Batchelor AM, Garthwaite J (1997) Frequency detection and temporally dispersed synaptic signal association through a metabotropic glutamate receptor pathway. Nature 385: 74\u201377.","journal-title":"Nature"},{"key":"5276998_CR4","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1016\/0306-4522(94)90558-4","volume":"63","author":"AM Batchelor","year":"1994","unstructured":"Batchelor AM, Madge DJ, Garthwaite J (1994) Synaptic activation of metabotropic glutamate receptors in the parallel fibre-Purkinje cell pathway in rat cerebellar slices. Neuroscience 63: 911\u2013915.","journal-title":"Neuroscience"},{"key":"5276998_CR5","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1098\/rstb.1988.0080","volume":"320","author":"MJ Berridge","year":"1988","unstructured":"Berridge MJ, Cobbold PH, Cuthbertson KSR (1988) Spatial and temporal aspects of cell signalling. Phil. Trans. R. Soc. Lond. B 320: 325\u2013343.","journal-title":"Phil. Trans. R. Soc. Lond. B"},{"key":"5276998_CR6","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1038\/351751a0","volume":"351","author":"I Bezprozvanny","year":"1991","unstructured":"Bezprozvanny I, Watras J, Ehrlich BE (1991) Bell-shaped calciumdependent curves of Ins(l,4,5)-P3 gated and calcium gated channels from endoplasmic reticulum of cerebellum. Nature 351: 751\u2013754.","journal-title":"Nature"},{"key":"5276998_CR7","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1126\/science.283.5400.381","volume":"283","author":"US Bhalla","year":"1999","unstructured":"Bhalla US, Iyengar R (1999) Emergent properties of networks of biological signaling pathways. Science 283: 381\u2013387.","journal-title":"Science"},{"key":"5276998_CR8","doi-asserted-by":"crossref","first-page":"1854","DOI":"10.1126\/science.2063199","volume":"252","author":"W Bialek","year":"1991","unstructured":"Bialek W, Rieke F, de Ruyter van Steveninck R, Warland D (1991) Reading a neural code. Science 252: 1854\u20131857.","journal-title":"Science"},{"key":"5276998_CR9","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1088\/0954-898X_9_1_006","volume":"9","author":"KT Blackwell","year":"1998","unstructured":"Blackwell KT, Vogl TP, Alkon DL (1998) Pattern matching in a model of dendritic spines. Network 9: 107\u2013121.","journal-title":"Network"},{"key":"5276998_CR10","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1152\/jn.1971.34.1.17","volume":"34","author":"JR Bloedel","year":"1971","unstructured":"Bloedel JR, Roberts WJ(1971) Action of climbing fibres in cerebellar cortex of the cat. J. Neurophysiol. 34: 17\u201331.","journal-title":"J. Neurophysiol."},{"key":"5276998_CR11","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1038\/386284a0","volume":"386","author":"PR Brakeman","year":"1997","unstructured":"Brakeman PR, Lanahan AA, O'Brien R, Roche K, Barnes CA, Huganir RL, Worely FP (1997) Homer: A protein that selectively binds metabotropic glutamate receptors. Nature 386: 284\u2013288.","journal-title":"Nature"},{"key":"5276998_CR12","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/376307a0","volume":"376","author":"BrayD","year":"1995","unstructured":"BrayD(1995) Protein molecules as computational elements in living cells. Nature 376: 307\u2013312.","journal-title":"Nature"},{"key":"5276998_CR13","doi-asserted-by":"publisher","first-page":"768","DOI":"10.1038\/347768a0","volume":"347","author":"DS Bredt","year":"1990","unstructured":"Bredt DS, Hwang PM, Snyder SH (1990) Localization of nitric oxide synthase indicating a neural role for nitric oxide. Nature 347:768\u2013770.","journal-title":"Nature"},{"key":"5276998_CR14","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1146\/annurev.bi.56.070187.002143","volume":"56","author":"E Carafoli","year":"1987","unstructured":"Carafoli E (1987) Intracellular calcium homeostasis. Ann. Rev. Biochem. 56: 395\u2013433.","journal-title":"Ann. Rev. Biochem."},{"key":"5276998_CR15","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1111\/1467-9280.00356","volume":"12","author":"RE Clark","year":"2001","unstructured":"Clark RE, Manns JR, Squire LR(2001)Trace and delay eyeblink conditioning: Contrasting phenomena of declarative and nondeclarative memory. Psychol. Sci. 12: 304\u2013308.","journal-title":"Psychol. Sci."},{"key":"5276998_CR16","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1016\/S0166-2236(98)01304-6","volume":"21","author":"H Daniel","year":"1998","unstructured":"Daniel H, Levenes C, Crepel F (1998) Cellular mechanisms of cerebellar LTD. Trends Neurosci. 21: 401\u2013407.","journal-title":"Trends Neurosci."},{"key":"5276998_CR17","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/0166-2236(95)93916-L","volume":"18","author":"E De Schutter","year":"1995","unstructured":"De Schutter E (1995) Cerebellar long-term depression might normalize excitation of Purkinje cells:Ahypothesis. Trends Neurosci. 18: 291\u2013295.","journal-title":"Trends Neurosci."},{"key":"5276998_CR18","first-page":"531","volume":"114","author":"E De Schutter","year":"1997","unstructured":"De Schutter E (1997) A new functional role for cerebellar long term depression. Prog. Brain Res. 114: 531\u2013544.","journal-title":"Prog. Brain Res."},{"key":"5276998_CR19","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1152\/jn.1994.71.1.401","volume":"71","author":"E De Schutter","year":"1994","unstructured":"De Schutter E, Bower JM (1994) An active membrane model of the cerebellar Purkinje cell. II. Simulation of synaptic responses. J. Neurophysiol 71: 401\u2013419.","journal-title":"J. Neurophysiol"},{"key":"5276998_CR20","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/BF00235911","volume":"15","author":"JC Eccles","year":"1972","unstructured":"Eccles JC, Sabah NH, Schmidt RF, Taborikova H (1972a) Cutaneous mechanoreceptors influencing impulse discharges in cerebellar cortex. 2. In Purkyne cells by mossy fiber input. Exp. Brain Res. 15: 261\u2013277.","journal-title":"Brain Res."},{"key":"5276998_CR21","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1007\/BF00236404","volume":"15","author":"JC Eccles","year":"1972","unstructured":"Eccles JC, Sabah NH, Schmidt RF, Taborikova H (1972b) Cutaneous mechanoreceptors influencing impulse discharges in cerebellar cortex. 3. In Purkyne cells by climbing fiber input. Exp. Brain Res. 15: 484\u2013497.","journal-title":"Exp. Brain Res."},{"key":"5276998_CR22","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/BFb0020149","volume-title":"Proceedings of the 7th International Conference on Artifical Neural Networks ICANN 97","author":"CW Eurich","year":"1997","unstructured":"Eurich CW, Cowan JD, Milton JG (1997) Hebbian delay adaptation in a network of integrate-and-fire neurons. In:W Gerstner, A Germond, M Hasler, JD Nicoud, eds. Proceedings of the 7th International Conference on Artifical Neural Networks ICANN 97, Springer Verlag, Berlin, pp. 157\u2013162."},{"key":"5276998_CR23","first-page":"355","volume-title":"Proceedings of the 8th International Conference on Artifical Neural Networks ICANN 98","author":"CW Eurich","year":"1998","unstructured":"Eurich CW, Ernst U, Pawelzik K (1998) Continous dynamics of neuronal delay adaptation. In: L Niklasson, M Bod\u00e9n, T Ziemke, eds. Proceedings of the 8th International Conference on Artifical Neural Networks ICANN 98, Springer Verlag, Berlin, pp. 355\u2013360."},{"key":"5276998_CR24","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1111\/j.1460-9568.1991.tb01674.x","volume":"3","author":"L Fagni","year":"1991","unstructured":"Fagni L, Bossu JL, Bockaert J (1991) Activation of a Largeconductance Ca2+-DependentK+ Channel by Stimulation of Glutamate Phosphoinositide-coupled Receptors in Cultured Cerebellar Granule Cells. Eur. J. Neurosci. 3: 778\u2013789.","journal-title":"Eur. J. Neurosci."},{"key":"5276998_CR25","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/S0166-2236(99)01492-7","volume":"23","author":"L Fagni","year":"2000","unstructured":"Fagni L, Chavis P, Ango F, Bockaert J (2000) Complex interactions between mGluRs, intracellular Ca2+ stores and ion channels in neurons. Trends Neurosci. 23: 80\u201388.","journal-title":"Trends Neurosci."},{"key":"5276998_CR26","doi-asserted-by":"crossref","first-page":"3760","DOI":"10.1523\/JNEUROSCI.16-11-03760.1996","volume":"16","author":"JC Fiala","year":"1996","unstructured":"Fiala JC, Grossberg S, Bullock D (1996) Metabotropic glutamate receptor activation in cerebellar Purkinje cells as substrate for adaptive timing of the classically conditioned eye-blink response. J. Neurosci. 16: 3760\u20133774.","journal-title":"J. Neurosci."},{"key":"5276998_CR27","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1038\/25541","volume":"396","author":"EA Finch","year":"1998","unstructured":"Finch EA, Augustine GJ (1998) Local calcium signalling by inositol-1,4,5-trisphosphate in Purkinje cell dendrites. Nature 396: 753\u2013756.","journal-title":"Nature"},{"key":"5276998_CR28","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1038\/27771","volume":"394","author":"CD Fiorillo","year":"1998","unstructured":"Fiorillo CD, Williams JT (1998) Glutamate mediates an inhibitory postsynaptic potential in dopamine neurons. Nature 394: 19\u201321.","journal-title":"Nature"},{"key":"5276998_CR29","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1038\/383076a0","volume":"383","author":"W Gerstner","year":"1996","unstructured":"Gerstner W, Kempter R, van Hemmen J, Wagner H(1996)Aneuronal learning rule for sub-millisecond temporal coding. Nature 383: 76\u201378.","journal-title":"Nature"},{"key":"5276998_CR30","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/BF00235210","volume":"1","author":"J Hamori","year":"1966","unstructured":"Hamori J, Szentagothai J (1966) Identification under the electron microscope of climbing fibers and their synaptic contacts. Exp. Brain Res. 1: 65\u201381.","journal-title":"Exp. Brain Res."},{"key":"5276998_CR31","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1038\/87419","volume":"4","author":"C Hansel","year":"2001","unstructured":"Hansel C, Linden DJ, D'Angelo E (2001) Beyond parallel fiber LTD: The diversity of synaptic and non-synaptic plasticity in the cerebellum. Nat. Neurosci. 4: 467\u2013475.","journal-title":"Nat. Neurosci."},{"key":"5276998_CR32","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/0006-8993(95)01406-3","volume":"711","author":"N Harata","year":"1996","unstructured":"Harata N, Katayama J, Takeshita Y, Murai Y, Akaike N (1996) Two components of metabotropic glutamate responses in acutely dissociated CA3 pyramidal neurons of the rat. Brain Res. 711: 223\u2013233.","journal-title":"Brain Res."},{"key":"5276998_CR33","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1097\/00001756-199403000-00024","volume":"5","author":"NA Hartell","year":"1994","unstructured":"Hartell NA (1994) cGMP acts within cerebellar Purkinje cells to produce long term depression via mechanisms involving PKC and PKG. Neuroreport 5: 833\u2013836.","journal-title":"Neuroreport"},{"key":"5276998_CR34","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1113\/jphysiol.1987.sp016743","volume":"391","author":"AL Hodgkin","year":"1987","unstructured":"Hodgkin AL, Nunn BJ (1987) The effect of ions on sodium-calcium exchange in salamander rods. J. Physiol. 391: 371\u2013398.","journal-title":"J. Physiol."},{"key":"5276998_CR35","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1007\/BF03000295","volume":"11","author":"FK Hoehler","year":"1976","unstructured":"Hoehler FK, Leonard DW(1976) Double responding in classical nictitating membrane conditioning with single-CS dual-ISI training. Pavlov J. Biol. Sci. 11: 180\u2013190.","journal-title":"Pavlov J. Biol. Sci."},{"key":"5276998_CR36","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1038\/376033a0","volume":"376","author":"JJ Hopfield","year":"1995","unstructured":"Hopfield JJ (1995) Pattern recognition computation using action potential timing for stimulus representation. Nature 376: 33\u201336.","journal-title":"Nature"},{"key":"5276998_CR37","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S0079-6123(08)61720-3","volume":"89","author":"K-P Huang","year":"1991","unstructured":"Huang K-P, Huang FL, Mahoney CW, Chen K-H (1991) Protein kinase C subtypes and their respective roles. Prog. Brain Res. 89: 143\u2013155.","journal-title":"Prog. Brain Res."},{"key":"5276998_CR38","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1162\/089976698300017665","volume":"10","author":"H Huning","year":"1998","unstructured":"Huning H, Glunder H, Palm G (1998) Synaptic delay learning in pulse-coupled neurons. Neural Comp. 10: 555\u2013565.","journal-title":"Neural Comp."},{"key":"5276998_CR39","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/0166-2236(96)81860-1","volume":"19","author":"M Ito","year":"1996","unstructured":"Ito M (1996) The new hypothesis does not detract from the MAIT theory. Trends Neurosci. 19: 11.","journal-title":"Trends Neurosci."},{"key":"5276998_CR40","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0168-0102(05)80004-5","volume":"14","author":"M Ito","year":"1992","unstructured":"Ito M, Karachot L (1992) Protein kinases and phosphatase inhibitors mediating long-term desensitization of glutamate receptors in cerebellar Purkinje cells. Neuroscience Res. 14: 27\u201338.","journal-title":"Neuroscience Res."},{"key":"5276998_CR41","first-page":"133","volume":"324","author":"M Ito","year":"1982","unstructured":"Ito M, Sakurai M, Tongroach P (1982) Climbing fibre induced depression of both mossy fibre responsiveness and glutamate sensitivity of cerebellar Purkinje cells. J. Physiol. 324: 133\u2013134.","journal-title":"J. Physiol."},{"key":"5276998_CR42","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/0166-4328(87)90048-9","volume":"23","author":"GO James","year":"1987","unstructured":"James GO, Hardiman MJ, Yeo CH (1987) Hippocampal lesions and trace conditioning in the rabbit. Behav. Brain Res. 23: 109\u2013116.","journal-title":"Behav. Brain Res."},{"key":"5276998_CR43","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/0168-0102(94)90158-9","volume":"21","author":"L Karachot","year":"1994","unstructured":"Karachot L, Kado RT, Ito M (1994) Stimulus parameters for induction of long-term depression in in vitro rat Purkinje cells. Neurosci. Res. 21: 161\u2013168.","journal-title":"Neurosci. Res."},{"key":"5276998_CR44","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1037\/\/0735-7044.103.2.283","volume":"103","author":"EJ Kehoe","year":"1989","unstructured":"Kehoe EJ, Graham-Clarke P, Schreurs BG (1989) Temporal patterns of the rabbit's nictitating membrane response to compound and component stimuli under mixed CS-US intervals. Behav. Neurosci. 103: 283\u2013295.","journal-title":"Behav. Neurosci."},{"key":"5276998_CR45","doi-asserted-by":"crossref","first-page":"4976","DOI":"10.1073\/pnas.90.11.4976","volume":"90","author":"K Khodakhah","year":"1993","unstructured":"Khodakhah K, Ogden D (1993) Functional heterogeneity of calcium release by inositol trisphosphate in single Purkinje neurones, cultured cerebellar astrocytes, and peripheral tissues. Proc. Natl. Acad. Sci. USA 90: 4976\u20134980.","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"5276998_CR46","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1113\/jphysiol.1995.sp020884","volume":"487","author":"K Khodakhah","year":"1995","unstructured":"Khodakhah K, Ogden D (1995) Fast activation and inactivation of inositol trisphosphate-evoked Ca2+ release in rat cerebellar Purkinje neurones. J. Physiol. 487: 343\u2013358.","journal-title":"J. Physiol."},{"key":"5276998_CR47","doi-asserted-by":"publisher","first-page":"1221","DOI":"10.1046\/j.0953-816x.2001.01486.x","volume":"13","author":"Y Kishimoto","year":"2001","unstructured":"Kishimoto Y, Kawahara S, Mori H, Mishina M, Kirino Y (2001) Long-trace interval eyeblink conditioning is impaired in mutant mice lacking the NMDA receptor subunit epsilon 1. Eur. J. Neurosci. 13: 1221\u20131227.","journal-title":"Eur. J. Neurosci."},{"key":"5276998_CR48","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1016\/S0166-2236(96)10054-0","volume":"19","author":"G Laurent","year":"1996","unstructured":"Laurent G (1996) Dynamical representation of odors by oscillating and evolving neural assemblies. Trends Neurosci. 19: 489\u2013496.","journal-title":"Trends Neurosci."},{"key":"5276998_CR49","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.1016\/S0896-6273(00)80340-2","volume":"18","author":"V Lev-Ram","year":"1997","unstructured":"Lev-Ram V, Jiang T, Wood J, Lawrence DS, Tsien RY (1997) Synergies and coincidence requirements between NO, cGMP, and Ca2+ in the induction of cerebellar long-term depression. Neuron 18: 1025\u20131038.","journal-title":"Neuron"},{"key":"5276998_CR50","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1016\/0959-4388(93)90133-J","volume":"3","author":"DJ Linden","year":"1993","unstructured":"Linden DJ, Connor JA (1993) Cellular mechanisms of long-term depression in the cerebellum. Curr. Opin. Neurobiol. 3: 401\u2013406.","journal-title":"Curr. Opin. Neurobiol."},{"key":"5276998_CR51","doi-asserted-by":"crossref","first-page":"14483","DOI":"10.1016\/S0021-9258(19)49738-X","volume":"267","author":"J Lytton","year":"1992","unstructured":"Lytton J, Westlin M, Burk SE, Shull GE, MacLennan DH (1992) Functional comparisons between isoforms of the sarcoplasmic or endoplasmic reticulum family of calcium pumps. J. Biol. Chem. 267: 14483\u201314489.","journal-title":"J. Biol. Chem."},{"key":"5276998_CR52","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/0014-5793(90)80831-3","volume":"277","author":"RM Marais","year":"1990","unstructured":"Marais RM, Nguyen O, Woodgett JR, Parker PJ (1990) Studies of the primary sequence requirements for PKC-\u03b1,-\u03b21 and-?peptide substrates. FEBS letters 277: 151\u2013155.","journal-title":"FEBS letters"},{"key":"5276998_CR53","doi-asserted-by":"publisher","first-page":"760","DOI":"10.1038\/349760a0","volume":"349","author":"M Masu","year":"1991","unstructured":"Masu M, Tanabe Y, Tsuchida K, Shigemoto R, Nakanishi S (1991) Sequence and expression of a metabotropic glutamate receptor. Nature 349: 760\u2013765.","journal-title":"Nature"},{"key":"5276998_CR54","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1126\/science.6701513","volume":"223","author":"DA McCormick","year":"1984","unstructured":"McCormick DA, Thompson RF (1984) Cerebellum: Essential involvement in the classically conditioned eyelid response. Science 223: 296\u2013299.","journal-title":"Science"},{"key":"5276998_CR55","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.1152\/jn.2001.86.4.1839","volume":"86","author":"MD McEchron","year":"2001","unstructured":"McEchron MD, Weible AP, Disterhoft JF (2001) Aging and learningspecific changes in single-neuron activity in CA1 hippocampus during rabbit trace eyeblink conditioning. J. Neurophysiol. 86: 1839\u20131857.","journal-title":"J. Neurophysiol."},{"key":"5276998_CR56","doi-asserted-by":"crossref","first-page":"5516","DOI":"10.1523\/JNEUROSCI.20-14-05516.2000","volume":"20","author":"JF Medina","year":"2000","unstructured":"Medina JF, Garcia KS, Nores WL, Taylor NM, Mauk MD (2000) Timing mechanisms in the cerebellum: Testing predictions of a large-scale computer simulation. J. Neurosci. 20: 5516\u20135525.","journal-title":"J. Neurosci."},{"key":"5276998_CR57","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1021\/bi00349a033","volume":"25","author":"G Meissner","year":"1986","unstructured":"Meissner G, Darling E, Eveleth J (1986) Kinetics of rapid Ca2+ release by sarcoplasmic reticulum. Effects of Ca2+, Mg2+ and adenine nucleotides. Biochemistry 25: 236\u2013244.","journal-title":"Biochemistry"},{"key":"5276998_CR58","doi-asserted-by":"crossref","first-page":"7450","DOI":"10.1016\/S0021-9258(18)42538-0","volume":"267","author":"GA Mignery","year":"1992","unstructured":"Mignery GA, Johnston PA, Sudhof TC (1992) Mechanism of Ca2+ inhibition of inositol 1,4,5-trisphosphate (InsP3) binding to the cerebellar InsP3 receptor. J. Biol. Chem. 267: 7450\u20137455.","journal-title":"J. Biol. Chem."},{"key":"5276998_CR59","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1037\/\/0735-7044.104.2.243","volume":"104","author":"JRJ Moyer","year":"1990","unstructured":"Moyer JRJ, Deyo RA, Disterhoft JF (1990) Hippocampectomy disrupts trace eye-blink conditioning in rabbits. Behav. Neurosc. 104: 243\u2013252.","journal-title":"Behav. Neurosc."},{"key":"5276998_CR60","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1016\/0006-8993(70)90259-3","volume":"17","author":"JT Murphy","year":"1970","unstructured":"Murphy JT, Sabah NH (1970) Spontaneous firing of cerebellar Purkinje cells in decerebrate and barbiturate anesthesized cats. Brain Res. 17: 515\u2013519.","journal-title":"Brain Res."},{"key":"5276998_CR61","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1007\/BF00206711","volume":"74","author":"H Napp-Zinn","year":"1996","unstructured":"Napp-Zinn H, Jansen M, Eckmiller R (1996) Recognition and tracking of impulse patterns with delay adaptation in biology-inspired pulse processing neural net (BPN) hardware. Biol. Cybernetics 74: 449\u2013453.","journal-title":"Biol. Cybernetics"},{"key":"5276998_CR62","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1088\/0954-898X_9_3_003","volume":"9","author":"T Natschlager","year":"1998","unstructured":"Natschlager T, Ruf B (1998) Spatial and temporal pattern analysis via spiking neurons. Network 9: 319\u2013332.","journal-title":"Network"},{"key":"5276998_CR63","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1152\/jn.1997.78.1.63","volume":"78","author":"JG Netzeband","year":"1997","unstructured":"Netzeband JG, Parsons KL, Sweeney DD, Gruol DL (1997) Metabotropic glutamate receptor agonists alter neuronal excitability and Ca2+ levels via the phospholipase C transduction pathway in cultured Purkinje neurons. J. Neurophysiol. 78: 63\u201375.","journal-title":"J. Neurophysiol."},{"key":"5276998_CR64","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0079-6123(08)61719-7","volume":"89","author":"Y Nishizuka","year":"1991","unstructured":"Nishizuka Y, Shearman MS, Oda T, Berry N, Tanaka C(1991) Protein kinase C family and nervous function. Prog. Brain Res. 89: 125\u2013141.","journal-title":"Prog. Brain Res."},{"key":"5276998_CR65","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1523\/JNEUROSCI.21-02-00682.2001","volume":"21","author":"T Ohyama","year":"2001","unstructured":"Ohyama T, Mauk MD (2001) Latent acquisition of timed responses in cerebellar cortex. J. Neurosci. 21: 682\u2013690.","journal-title":"J. Neurosci."},{"key":"5276998_CR66","doi-asserted-by":"crossref","first-page":"7208","DOI":"10.1523\/JNEUROSCI.14-11-07208.1994","volume":"14","author":"DG Rainnie","year":"1994","unstructured":"Rainnie DG, Holmes KH, Shinnick-Gallagher P (1994) Activation of postsynaptic metabotropic glutamate receptors by trans-ACPD hyperpolarizes neurons of the basolateral amygdala. J. Neurosci. 14: 7208\u20137220.","journal-title":"J. Neurosci."},{"key":"5276998_CR67","volume-title":"Spikes: Exploring the Neural Code","author":"F Rieke","year":"1997","unstructured":"Rieke F, Warland D, de Ruyter van Steveninck R, Bialek W (1997) Spikes: Exploring the Neural Code. MIT Press, Cambridge, MA."},{"key":"5276998_CR68","doi-asserted-by":"crossref","first-page":"435","DOI":"10.3758\/BF03199799","volume":"11","author":"RT Ross","year":"1983","unstructured":"Ross RT, Scavio MJJ (1983) Perseveration of associative strength in rabbit nictitating membrane conditioning following ISI shifts. Anim. Learn. Behav. 11: 435\u2013438.","journal-title":"Anim. Learn. Behav."},{"key":"5276998_CR69","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/0006-8993(93)91540-9","volume":"631","author":"BG Schreurs","year":"1993","unstructured":"Schreurs BG, Alkon DL (1993) Rabbit cerebellar slice analysis of long-term depression and its role in classical conditioning. Brain Res. 631: 235\u2013240.","journal-title":"Brain Res."},{"key":"5276998_CR70","doi-asserted-by":"publisher","first-page":"10661","DOI":"10.1073\/pnas.97.19.10661","volume":"97","author":"N Schweighofer","year":"2000","unstructured":"Schweighofer N, Ferriol G (2000) Diffusion of nitric oxide can facilitate cerebellar learning: A simulation study. Proc. Natl. Acad. Sci. USA 97: 10661\u201310665.","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"5276998_CR71","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1038\/376021a0","volume":"376","author":"TJ Sejnowski","year":"1995","unstructured":"Sejnowski TJ (1995) Time for a newneural code? Nature 376: 21\u201322.","journal-title":"Nature"},{"key":"5276998_CR72","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1038\/349326a0","volume":"349","author":"K Shibuki","year":"1991","unstructured":"Shibuki K, Okada D(1991) Endogenous nitric oxide release required for long-term synaptic depression in the cerebellum. Nature 349: 326\u2013328.","journal-title":"Nature"},{"key":"5276998_CR73","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1037\/\/0735-7044.100.5.729","volume":"100","author":"PR Solomon","year":"1986","unstructured":"Solomon PR, Vander Schaaf ER, Thompson RF, Weisz DJ (1986) Hippocampus and trace conditioning of the rabbit's classically conditioned eye-blink response. Behav. Neurosci. 100: 729\u2013744.","journal-title":"Behav. Neurosci."},{"key":"5276998_CR74","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/0166-4328(90)90008-3","volume":"38","author":"JE Steinmetz","year":"1990","unstructured":"Steinmetz JE (1990) Classical nictitating membrane conditioning in rabbits with varying interstimulus intervals and direct activation of cerebellar mossy fibres as the CS. Behav. Brain Res. 38: 97\u2013108.","journal-title":"Behav. Brain Res."},{"key":"5276998_CR75","doi-asserted-by":"crossref","first-page":"6859","DOI":"10.1021\/bi00188a015","volume":"33","author":"PM Stemmer","year":"1994","unstructured":"Stemmer PM, Klee CB (1994) Dual calcium ion regulation of calcineurin by calmodulin and calcineurin B. Biochemistry 33: 6859\u20136866.","journal-title":"Biochemistry"},{"key":"5276998_CR76","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/BFb0020142","volume-title":"Proceedings of the 7th International Conference on Artifical Neural Networks ICANN 97","author":"V Steuber","year":"1997","unstructured":"Steuber V, Willshaw DJ (1997) How a single Purkinje cell could learn the adaptive timing of the classically conditioned eye-blink response. In: W Gerstner, A Germond, M Hasler, JD Nicoud, eds. Proceedings of the 7th International Conference on Artifical Neural Networks ICANN 97, Springer Verlag, Berlin, pp. 115\u2013120."},{"key":"5276998_CR77","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/S0925-2312(99)00021-1","volume":"26","author":"V Steuber","year":"1999","unstructured":"Steuber V, Willshaw DJ (1999) Adaptive leaky integrator models of cerebellar Purkinje cells can learn the clustering of temporal patterns. Neurocomputing 26: 271\u2013276.","journal-title":"Neurocomputing"},{"key":"5276998_CR78","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1016\/S0028-3908(01)00113-7","volume":"41","author":"K Takatsuki","year":"2001","unstructured":"Takatsuki K, Kawahara S, Takehara K, Kishimoto Y, Kirino Y(2001) Effects of the noncompetitiveNMDAreceptor antagonist MK-801 on classical eyeblink conditioning in mice. Neuropharmacology 41: 618\u2013628.","journal-title":"Neuropharmacology"},{"key":"5276998_CR79","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1152\/jn.1998.80.2.520","volume":"80","author":"F Tempia","year":"1998","unstructured":"Tempia F, Miniaci MC, Anchisi D, Strata P (1998) Postsynaptic currents mediated by metabotropic glutamate receptors in cerebellar Purkinje cells. J. Neurophysiol. 80: 520\u2013528.","journal-title":"J. Neurophysiol."},{"key":"5276998_CR80","doi-asserted-by":"publisher","first-page":"13438","DOI":"10.1073\/pnas.93.24.13438","volume":"93","author":"RF Thompson","year":"1996","unstructured":"Thompson RF, Kim JJ (1996) Memory systems in the brain and localization of a memory. Proc. Natl. Acad. Sci. USA 93: 13438\u201313444.","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"5276998_CR81","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1146\/annurev.ne.17.030194.002511","volume":"17","author":"RF Thompson","year":"1994","unstructured":"Thompson RF, Krupa DJ (1994) Organization of memory traces in the mammalian brain. Ann. Rev. Neurosci. 17: 519\u2013549.","journal-title":"Ann. Rev. Neurosci."},{"key":"5276998_CR82","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1038\/381520a0","volume":"381","author":"S Thorpe","year":"1996","unstructured":"Thorpe S, Fize F, Marlot C (1996) Speed of processing in the human visual system. Nature 381: 520\u2013522.","journal-title":"Nature"},{"key":"5276998_CR83","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1016\/S0896-6273(00)80589-9","volume":"21","author":"JC Tu","year":"1998","unstructured":"Tu JC, Xiao B, Yuan JP, Lanahan AA, Leoffert K, Li M, Linden DJ, Worley PF (1998) Homer binds a novel proline-rich motif and links group 1 metabotropic glutamate receptors with IP3 receptors. Neuron 21: 717\u2013726.","journal-title":"Neuron"},{"key":"5276998_CR84","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1016\/0306-4522(92)90184-4","volume":"46","author":"SR Vincent","year":"1992","unstructured":"Vincent SR, Kimura H(1992) Histochemical mapping of nitric oxide synthase in the rat brain. Neuroscience 46: 755\u2013784.","journal-title":"Neuroscience"},{"key":"5276998_CR85","doi-asserted-by":"publisher","first-page":"1266","DOI":"10.1038\/81792","volume":"3","author":"SS Wang","year":"2000","unstructured":"Wang SS, Denk W, Hausser M(2000) Coincidence detection in single dendritic spines mediated by calcium release. Nat. Neurosci. 3: 1266\u20131273.","journal-title":"Nat. Neurosci."},{"key":"5276998_CR86","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1038\/384162a0","volume":"384","author":"M Wehr","year":"1996","unstructured":"Wehr M, Laurent G (1996) Odour encoding by temporal sequences of firing in oscillating neural assemblies. Nature 384: 162\u2013166.","journal-title":"Nature"},{"key":"5276998_CR87","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/0006-8993(85)90443-3","volume":"348","author":"DS Woodruff-Pak","year":"1985","unstructured":"Woodruff-Pak DS, Lavond DG, Thompson RF (1985) Trace conditioning: Abolished by cerebellar nuclear lesions but not lateral cerebellar cortex aspirations. Brain Res. 348: 249\u2013260.","journal-title":"Brain Res."},{"key":"5276998_CR88","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1016\/S1364-6613(98)01219-4","volume":"2","author":"CH Yeo","year":"1998","unstructured":"Yeo CH, Hesslow G (1998) Cerebellum and conditioned reflexes. Trends Cognitive Sci. 2: 322\u2013330.","journal-title":"Trends Cognitive Sci."},{"key":"5276998_CR89","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1101\/lm.3.6.557","volume":"3","author":"CH Yeo","year":"1997","unstructured":"Yeo CH, Lobo DH, Baum A (1997) Acquisition of a new-latency conditioned nictitating membrane response-Major, but not complete, dependence on the ipsilateral cerebellum. Learn. Mem. 3: 557\u2013577.","journal-title":"Learn. Mem."}],"container-title":["Journal of Computational Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/B:JCNS.0000037678.26155.b5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1023\/B:JCNS.0000037678.26155.b5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/B:JCNS.0000037678.26155.b5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,6]],"date-time":"2025-06-06T09:44:38Z","timestamp":1749203078000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1023\/B:JCNS.0000037678.26155.b5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,9]]},"references-count":89,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2004,9]]}},"alternative-id":["5276998"],"URL":"https:\/\/doi.org\/10.1023\/b:jcns.0000037678.26155.b5","relation":{},"ISSN":["0929-5313","1573-6873"],"issn-type":[{"type":"print","value":"0929-5313"},{"type":"electronic","value":"1573-6873"}],"subject":[],"published":{"date-parts":[[2004,9]]}}}