LOCF

They were included in the final analysis in a last observation carried forward.

Two populations were used for statistical analysis, the intent-to-treat population with the last observation carried forward (ITT-LOCF) and the completers population.

Specifically, it has been argued that the last observation carried forward (LOCF) method is inappropriate because it assumes that the participants' condition is stable at the value observed before dropout.(3) As Molnar et al.(3) reported, when more dropouts occur in the treatment group than the placebo group, the LOCF approach causes a bias in the results in favor of the test treatment.(3) In fact, the bias caused by the LOCF approach has been demonstrated in simulation studies using knee OA data (4) and rheumatoid arthritis (RA) and osteoarthritis (OA) data.(5)

An intention-to-treat analysis ("last observation carried forward" method) was used with a Student's t-test for normally distributed variables.

In the intent-to-treat (ITT) analysis with the last observation carried forward (LOCF), the weight loss percentages were 2%, 5%, and 11%, respectively, said Dr.

The secondary analysis with last observation carried forward yielded similar results.

Study results were based on the Last Observation Carried Forward (LOCF) method.

Analysis was based on last observation carried forward. Response to treatment was defined as a 75% reduction from baseline in hot flush frequency.

* carry forward the last available measurement as the final result, known as last observation carried forward (LOCF).

The primary analysis was based on the intent-to-treat population using a last observation carried forward analysis at 24 weeks.

Dropouts due to nitroglycerin-induced headache would have the last observation carried forward rather than the standard mixed-effects regression model, a methodology that the company objected to but that the FDA insisted on, Dr.