DCLHB

Using the criteria established under CLIA-88 to evaluate clinically significant interference, we investigated four analytes measured on the Hitachi 747 for interference caused by the presence of DCLHb. The range of analyte concentrations evaluated for interference by DCLHb included the 1st and 99th percentiles of patient test results reported in our laboratory (Table 1).

DCLHb interfered with the measurement of calcium, cholesterol, and total bilirubin, but did not interfere with measurement of potassium.

This indicates that DCLHb interferes with the determination of calcium in a manner that is not dependent on calcium concentrations.

For cholesterol, interference was dependent on the concentration of DCLHb only.

Measurement of total bilirubin was affected by the presence of DCLHb. The interference effect observed was proportional to the concentration of DCLHb, as well as the concentration of bilirubin.