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Besides what was already mentioned, I also use these tricks:

  • If by any chance the unresponsive program was started in a terminal, I try Ctrl+D or Ctrl+C. If nothing happens I try Ctrl+Z followed by a ruthless kill.

  • If I know the responsible program, I open a terminal and use killall (e.g. killall firefox).

  • Alternatively, under Gnome, I launch run command and invoke xkill, which allows you to kill a program by simply clicking on a window it owns.

  • Finally, just in case my keyboard melts, I have a System Monitor applet (also under Gnome) which will pop up the gnome-system-monitor when clicked. From there, I can kill any process I own using only my mouse.