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Ramesh
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Besides what was already mentioned, I also use those tricks:

  • If by any chance the unresponsive program was started in a terminal, I would try a Ctrl+D or Ctrl+C. If nothing happens I'd try a Ctrl+Z followed by a ruthless kill.

  • If I knew the responsible program, I would open a terminal and use killall. (E.g., killall firefox)

  • Alternatively, under Gnome, I would launch run command and invoke xkill, which allows you to kill a program by simply clicking on a window it owns.

  • Finally, just in case my keyboard melts, I have a System Monitor applet (also under Gnome) which will pop up the gnome-system-monitor when clicked. From there, I can kill any process I own using only my mouse.