For a specific column:
awk '{sub(/.*Chr/,"Chr",$3); print}' file
The first argument of sub is the pattern to match, the second is the replacement and last is the target. The outcome is stored to the target.
See also awk string functions.
And this is expandable for more columns, example:
awk '{sub(/.*Chr1/,"Chr1",$1); sub(/.*Chr2/,"Chr2",$2); print}' file
Note that matching is greedy as expected, which is the desired behaviour for your data.
To format the output, it's probably more convenient than defining OFS to pipe the output to column -t, for a tab-like pretty-printing with actual spaces, no tabs.