$ sed 's/^.*[[:<:]]Host[[:>:]].*$/replacement text/' file.intxt
The above will replace every line in the file file.intxt that contains the word Host with the string replacement text. The result will be given on standard output.
The [[:<:]] is a zero-length pattern that matches at the beginning of a word. Similarly, [[:>:]] will match at the end of a word. This means that the above substitution will not replace a line with the word Hostname or xHost on it (unless the word Host appears elsewhere on the line).