Edit your python program and let it check for a 'do not run' file first. If such file exists, exit your program i.e.
import os.path
if os.path.isfile('/tmp/disable_mypythondisable_mypython'): exit()
If you check for a file called for instance /tmp/disable_mypython you can easily 'disable' your program using:
touch /tmp/disable_mypython
and enable it again using:
rm /tmp/disable_mypython