Do you mean in Python or using ctypes?
In the first case, you simply cannot, because Python does not have signed/unsigned, 16/32 bit integers.
In the second case, you can use type():
>>> import ctypes
>>> a = ctypes.c_uint() # Unsigned int
>>> type(a)
<class 'ctypes.c_ulong'>
>>> import ctypes
>>> a = ctypes.c_uint() # Unsigned int
>>> type(a)
<class 'ctypes.c_ulong'>
For more references on ctypes, and its type, see the official documentation.