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    I believe that if you run in the python console, you could load the file once and then load other files / call functions separately, without having to reload the file Commented Jun 23, 2015 at 22:47
  • You must have a look at the pandas library for data handling. Manipulating data using it is a child's play. You will be able to grasp it fairly quickly if you have used R before. Specifically, you should have a look at the read_xxx functions in the documentation which allow you to load different file formats into a dataframe. Commented Jun 23, 2015 at 22:53