Firefox 3 doesntdoesn't seem to have a problem with huge numbers.
1e+200 * 1e+100 will calculate fine to 1e+300.
Safari seem to have no problem with it aswellas well. (For the record, this is on a Mac if anyone else decides to test this.)
Unless I lost my brain at this time of day, this is way bigger than a 64-bit integer.