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Regular expression problem

How can I search a whole string for a specific match. It'll contain both characters with int or decimal numbers eg A12B32.25C-456D-75.E75 I'll know that this will start with A and ends with E I think I can use "^" and "$" right? but i'm bit lost in other parts to check for character and int or decimal. I'll be glad if you can give the regex and explain it a bit :).

PS. D-75. is not mistyped...

Thanks in advance.