Well, it depends how you are getting the item.
If you are getting it via the URL like this:
/_api/lists/getbytitle('News')/items(50)
Where the number in the brackets "(50)" is the item ID you can get an item e.G. like this:
/_api/lists/getbytitle('News')/items?$filter=Title eq 'FAQ'
So the URL is looking for an item, where in the title column FAQ is the content.
In general:
/_api/lists/getbytitle('<ListName>')/items?$filter=<InternalColumnName> eq '<Value>'
To check the internal column names you can just use this:
/_api/lists/getbytitle('<ListName>')/items
Then use that name for the in the filter.
Hope this could help.