Of course, but let me show the process on simpler example and then just use same method for calculating final count.
Small example
We are given $2 \times 2$ square grid and two colors (black and white). We are trying to find out number of different coloring of this grid. Obviously, there are $2^4 = 16$ possible patterns, but we don't want to count symmetrical ones twice. To visualize problem, look at below table:

I've printed all $16$ cases, but I also grouped them by symmetry (there are $6$ different patterns). The key is to deeply analyze those symmetries. There are $8$ isometries of a square:
- Identity (or $0^\circ$ rotation)
- Rotations: $90^\circ$, $180^\circ$, $270^\circ$ rotations
- Reflections: x-axis, y-axis reflections and both diagonal reflections
From now, we'll call this set a group, also denoted as $D_4$ (more info about this particular group here)
Useful definitions
For some coloring $a$, let orbit of $a$ be the set of coloring patterns that are achievable from $a$ by applying on it any symmetry of a square (denoted as $\texttt{orb}(a)$). Example:

note: On the first table we grouped patterns into orbits.
For any isometry $g$, the set of its fixed points will be
all colorings of a such that $g(a) = a$ - we will denote this set
as $\texttt{fix}(g)$. Example (here $g$ is vertical reflection):

Our problem has been reduced to counting orbits. So let's jump right into Burnside lemma:
$$ | \Omega | = \frac{1}{|G|} \cdot \sum_{g \in G} | \texttt{fix}(g) | $$
Here $\Omega$ is set consisting all orbits, so finding $|\Omega|$ is our goal. Our group of symmetries is here denoted as $G$.
That's great because we don't care about set of possible colorings (which can have too many elements). The only difficulty left is calculation for each isometry how many fixed points it has. To do this, we have to look which of the corners of the square the given isometry transforms on which ones. This way we will break them down into cycles and each one will have to
be the same color. If an isometry has $k$ cycles, then it has $2^k$ fixed points, because we color each of them with one color.
For simplicity, let's enumerate corners of the square from $1$ to $4$. The table below shows what cycles will arise for all isometries. I encourage to do a thorough analysis.

And just plug this result into Burnside lemma:
$$ | \Omega | = \frac{2^4 + 2 \cdot 2^3 + 3 \cdot 2^2 + 2 \cdot 2 }{8} = \frac{48}{8} = 6 $$
Just as we expected.
side note: It's easy to generalize this process for any number of colors.
Final count
Now, when we have such a powerful mathematical machinery, we can proceed to calculate the proper count. This time we should take into consideration larger grid, hence we must analyze more complex cycles.
Let's start from identity. We have $16$ one-piece cycles, but only $6$ may be blue. Value of $\texttt{fix}$ for identity is $16 \choose 6$.
Then $90^\circ$ and $270^\circ$ rotation have $4$ cycles, each with $4$ elemets, we cannot color such gird using $6$ colors. Hence $\texttt{fix}$ for both this rotations is $0$.
Let's move on to $180^\circ$ rotation and both vertical and horizontal flips. All of these isometries has $8$ cycles, with $2$ elements in each. So we must color $3$ out of $8$ cycles to blue. Hence result for these three is $8 \choose 3$.
And lastly, both diagonal flips has $4$ single element cycles and $6$ containing two elements. So we can pick $4$, $2$ or $0$ from diagonal which sum up to $116 = 6 + 90 + 20 = 6 + {4 \choose 2} {6 \choose 2} + {6 \choose 3}$.
What gives longed-for result (denoted with $F$)
$$ F = \frac{8008 + 3 \cdot 56 + 2 \cdot 116}{8} = \frac{8408}{8} = 1051 $$